Characterization of fibril aggregates in ex vivo rat brain with multi- frequency MR Elastography -Preliminary results
Résumé
Fibrils are biomarkers for early stages of dementia. In this work, α-synuclein fibrils were injected in rat striatum. Brains were imaged ex-vivo using multi-frequency MR Elastography. Estimation of the real part k r of the complex wave number was made for each studied frequency in ROIs surrounding the inclusion, a contralateral control injection and the whole brain. Exponent of the frequency power law was derived from k r maps acquired at different frequencies. No difference was observed between k r values for the different ROIs, but the exponent was more important at the fibrils location, potentially indicating that multi-frequency MRE can detect fibrils.
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