Characterization of fibril aggregates in ex vivo rat brain with multi- frequency MR Elastography -Preliminary results - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2019

Characterization of fibril aggregates in ex vivo rat brain with multi- frequency MR Elastography -Preliminary results

Résumé

Fibrils are biomarkers for early stages of dementia. In this work, α-synuclein fibrils were injected in rat striatum. Brains were imaged ex-vivo using multi-frequency MR Elastography. Estimation of the real part k r of the complex wave number was made for each studied frequency in ROIs surrounding the inclusion, a contralateral control injection and the whole brain. Exponent of the frequency power law was derived from k r maps acquired at different frequencies. No difference was observed between k r values for the different ROIs, but the exponent was more important at the fibrils location, potentially indicating that multi-frequency MRE can detect fibrils.
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Dates et versions

hal-02266775 , version 1 (26-10-2020)

Identifiants

  • HAL Id : hal-02266775 , version 1

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Mathilde Bigot, Fabien Chauveau², Ralph Sinkus, Olivier Beuf, Simon Lambert. Characterization of fibril aggregates in ex vivo rat brain with multi- frequency MR Elastography -Preliminary results. 27th Annual meeting of the ISMRM, May 2019, Montreal, Belize. ⟨hal-02266775⟩
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