<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02266283</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T23:32:48+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Polyunsaturated fatty acids are potent neuroprotectors</title>
            <author role="aut">
              <persName>
                <forename type="first">Inger</forename>
                <surname>Lauritzen</surname>
              </persName>
              <idno type="halauthorid">344522-0</idno>
              <affiliation ref="#struct-199361"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Blondeau</surname>
              </persName>
              <email type="md5">d996d3b3179fafc03c6d6f1663d6f70e</email>
              <email type="domain">ipmc.cnrs.fr</email>
              <idno type="idhal" notation="string">nicolas-blondeau</idno>
              <idno type="idhal" notation="numeric">173093</idno>
              <idno type="halauthorid" notation="string">5118-173093</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5002-2016</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5954-4094</idno>
              <idno type="IDREF">https://www.idref.fr/074474936</idno>
              <affiliation ref="#struct-199361"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Heurteaux</surname>
              </persName>
              <idno type="halauthorid">227678-0</idno>
              <affiliation ref="#struct-199361"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Widmann</surname>
              </persName>
              <idno type="halauthorid">473706-0</idno>
              <affiliation ref="#struct-199361"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Georges</forename>
                <surname>Romey</surname>
              </persName>
              <idno type="halauthorid">1636321-0</idno>
              <affiliation ref="#struct-199361"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Lazdunski</surname>
              </persName>
              <idno type="halauthorid">226979-0</idno>
              <affiliation ref="#struct-199361"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Nicolas</forename>
                <surname>Blondeau</surname>
              </persName>
              <email type="md5">d996d3b3179fafc03c6d6f1663d6f70e</email>
              <email type="domain">ipmc.cnrs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-08-14 11:59:25</date>
              <date type="whenModified">2025-08-12 20:00:19</date>
              <date type="whenReleased">2019-08-14 15:43:43</date>
              <date type="whenProduced">2000</date>
              <date type="whenEndEmbargoed">2019-08-13</date>
              <ref type="file" target="https://hal.science/hal-02266283v1/document">
                <date notBefore="2019-08-13"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-02266283v1/file/2000-Lauritzen-EMBOJ.pdf" id="file-2266283-2188958">
                <date notBefore="2019-08-13"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC302016"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="665969">
                <persName>
                  <forename>Nicolas</forename>
                  <surname>Blondeau</surname>
                </persName>
                <email type="md5">d996d3b3179fafc03c6d6f1663d6f70e</email>
                <email type="domain">ipmc.cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02266283</idno>
            <idno type="halUri">https://hal.science/hal-02266283</idno>
            <idno type="halBibtex">lauritzen:hal-02266283</idno>
            <idno type="halRefHtml">&lt;i&gt;EMBO Journal&lt;/i&gt;, 2000, 19 (8), pp.1784-1793. &lt;a target="_blank" href="https://dx.doi.org/10.1093/emboj/19.8.1784"&gt;&amp;#x27E8;10.1093/emboj/19.8.1784&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">EMBO Journal, 2000, 19 (8), pp.1784-1793. &amp;#x27E8;10.1093/emboj/19.8.1784&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2266283-2188958"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNICE">Université Nice Sophia Antipolis</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-COTEDAZUR">Université Côte d'Azur</idno>
            <idno type="stamp" n="IPMC">Institut de pharmacologie moléculaire et cellulaire</idno>
            <idno type="stamp" n="TEST-NICE">test nice</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Polyunsaturated fatty acids are potent neuroprotectors</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Inger</forename>
                    <surname>Lauritzen</surname>
                  </persName>
                  <idno type="halauthorid">344522-0</idno>
                  <affiliation ref="#struct-199361"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Blondeau</surname>
                  </persName>
                  <email type="md5">d996d3b3179fafc03c6d6f1663d6f70e</email>
                  <email type="domain">ipmc.cnrs.fr</email>
                  <idno type="idhal" notation="string">nicolas-blondeau</idno>
                  <idno type="idhal" notation="numeric">173093</idno>
                  <idno type="halauthorid" notation="string">5118-173093</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5002-2016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5954-4094</idno>
                  <idno type="IDREF">https://www.idref.fr/074474936</idno>
                  <affiliation ref="#struct-199361"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Heurteaux</surname>
                  </persName>
                  <idno type="halauthorid">227678-0</idno>
                  <affiliation ref="#struct-199361"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Widmann</surname>
                  </persName>
                  <idno type="halauthorid">473706-0</idno>
                  <affiliation ref="#struct-199361"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Georges</forename>
                    <surname>Romey</surname>
                  </persName>
                  <idno type="halauthorid">1636321-0</idno>
                  <affiliation ref="#struct-199361"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Lazdunski</surname>
                  </persName>
                  <idno type="halauthorid">226979-0</idno>
                  <affiliation ref="#struct-199361"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">4598</idno>
                <idno type="issn">0261-4189</idno>
                <idno type="eissn">1460-2075</idno>
                <title level="j">EMBO Journal</title>
                <imprint>
                  <publisher>EMBO Press</publisher>
                  <biblScope unit="volume">19</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">1784-1793</biblScope>
                  <date type="datePub">2000</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/emboj/19.8.1784</idno>
              <idno type="pubmed">10775263</idno>
              <idno type="pubmedcentral">PMC302016</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
              <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Results reported in this work suggest a potential therapeutic value of polyunsaturated fatty acids for cerebral pathologies as previously proposed by others for cardiac diseases. We show that the polyunsatur-ated fatty acid linolenic acid prevents neuronal death in an animal model of transient global ischemia even when administered after the insult. Linolenic acid also protects animals treated with kainate against seizures and hippocampal lesions. The same effects have been observed in an in vitro model of seizure-like activity using glutamatergic neurons and they have been shown to be associated with blockade of glutamatergic transmission by low concentrations of distinct poly-unsaturated fatty acids. Our data suggest that the opening of background K + channels, like TREK-1 and TRAAK, which are activated by arachidonic acid and other polyunsaturated fatty acids such as docosahexa-enoic acid and linolenic acid, is a signi®cant factor in this neuroprotective effect. These channels are abundant in the brain where they are located both pre-and post-synaptically, and are insensitive to saturated fatty acids, which offer no neuroprotection.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-199361" status="VALID">
          <idno type="RNSR">201220332C</idno>
          <idno type="ROR">05k4ema52</idno>
          <orgName>Institut de pharmacologie moléculaire et cellulaire</orgName>
          <orgName type="acronym">IPMC</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>CNRS-IPMC 660 Route des lucioles 06560 VALBONNE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ipmc.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation name="UMR7275" active="#struct-441569" type="direct"/>
            <relation active="#struct-1039632" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-117617" status="VALID">
          <idno type="IdRef">026403498</idno>
          <idno type="ISNI">0000000123372892</idno>
          <idno type="ROR">https://ror.org/02k9vew78</idno>
          <orgName>Université Nice Sophia Antipolis (1965 - 2019)</orgName>
          <orgName type="acronym">UNS</orgName>
          <date type="start">1965-10-23</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Parc Valrose, 06100 Nice</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1039632" status="VALID">
          <idno type="IdRef">241035694</idno>
          <idno type="ROR">https://ror.org/019tgvf94</idno>
          <orgName>Université Côte d'Azur</orgName>
          <orgName type="acronym">UniCA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Parc Valrose, 28, avenue Valrose 06108 Nice Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://univ-cotedazur.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>