Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA
Résumé
The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences (ribozymes) are known to catalyse specific biochemical reactions with remarkable efficiencies, RNA-based catalysts involving a catalytically active metal complex interacting in a non-covalent fashion with short sequences have never been evaluated to date. We report here our results, which have led to the first example involving a short RNA-based catalyst.
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Duchemin%20Expanding%20biohybrid-mediated%20asymmetric%20catalysis%20into%20the%20realm%20of%20RNA%202016%20Accepted.pdf (2.5 Mo)
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