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            <title xml:lang="en">The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation</title>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Aslam</surname>
              </persName>
              <idno type="halauthorid">1628128-0</idno>
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            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Mittal</surname>
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            <author role="aut">
              <persName>
                <forename type="first">F.</forename>
                <surname>Koch</surname>
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              <idno type="halauthorid">210102-0</idno>
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            <author role="aut">
              <persName>
                <forename type="first">J. C.</forename>
                <surname>Andrau</surname>
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              <email type="md5">123a354132534d50525eac7ae3a70f45</email>
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                <forename type="first">G. S.</forename>
                <surname>Winkler</surname>
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                <forename>Sarah</forename>
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              <date type="whenModified">2024-11-08 09:54:03</date>
              <date type="whenReleased">2019-07-25 11:06:33</date>
              <date type="whenProduced">2009</date>
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            <idno type="halRefHtml">&lt;i&gt;Molecular Biology of the Cell&lt;/i&gt;, 2009, 20 (17), pp.3840--50. &lt;a target="_blank" href="https://dx.doi.org/10.1091/mbc.E09-02-0146"&gt;&amp;#x27E8;10.1091/mbc.E09-02-0146&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Molecular Biology of the Cell, 2009, 20 (17), pp.3840--50. &amp;#x27E8;10.1091/mbc.E09-02-0146&amp;#x27E9;</idno>
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            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGMM">Institut de génétique moléculaire de Montpellier</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
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                <title xml:lang="en">The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation</title>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Aslam</surname>
                  </persName>
                  <idno type="halauthorid">1628128-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Mittal</surname>
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                  <idno type="halauthorid">1546664-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F.</forename>
                    <surname>Koch</surname>
                  </persName>
                  <idno type="halauthorid">210102-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J. C.</forename>
                    <surname>Andrau</surname>
                  </persName>
                  <email type="md5">123a354132534d50525eac7ae3a70f45</email>
                  <email type="domain">igmm.cnrs.fr</email>
                  <idno type="idhal" notation="string">jean-christophe-andrau</idno>
                  <idno type="idhal" notation="numeric">740768</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">G. S.</forename>
                    <surname>Winkler</surname>
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                  <idno type="halauthorid">1628129-0</idno>
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                <idno type="eissn">1939-4586</idno>
                <title level="j">Molecular Biology of the Cell</title>
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                  <publisher>American Society for Cell Biology</publisher>
                  <biblScope unit="volume">20</biblScope>
                  <biblScope unit="issue">17</biblScope>
                  <biblScope unit="pp">3840--50</biblScope>
                  <date type="datePub">2009</date>
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              <idno type="doi">10.1091/mbc.E09-02-0146</idno>
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                <term xml:lang="en">Small Interfering/genetics/metabolism Ribonucleases/chemistry/genetics/*metabolism Transcription Factors/chemistry/genetics/*metabolism</term>
                <term xml:lang="en">Molecular Multiprotein Complexes/metabolism Myelin Proteins/genetics/metabolism Protein Subunits/genetics/*metabolism Proteins/chemistry/genetics/metabolism RNA Stability RNA</term>
                <term xml:lang="en">Animals Cell Line *Cell Proliferation Cyclin G2/genetics/metabolism Gene Expression Profiling Gene Expression Regulation Gene Knockdown Techniques Humans Male Mice Models</term>
              </keywords>
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              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
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              <p>Accurate gene expression requires the precise control of mRNA levels, which are determined by the relative rates of nuclear (pre-)mRNA synthesis and processing, and cytoplasmic mRNA turnover. A key step in mRNA degradation is the removal of the poly(A) tail, which involves several deadenylases including components of the Ccr4-Not complex. Here, we focused on the role of the human paralogues CNOT7 (hCaf1/Caf1a) and CNOT8 (hPop2/Caf1b/Calif), which possess deadenylase activity mediated by DEDD nuclease domains. We show that efficient proliferation requires both subunits, although combined knockdown of CNOT7 and CNOT8 further reduces cell proliferation indicating partial redundancy between these proteins. Interestingly, the function of CNOT7 in cell proliferation partly depends on its catalytic activity. On the other hand, the interaction between CNOT7 and BTG2, a member of the antiproliferative BTG/Tob family involved in transcription and mRNA decay appears less important for proliferation of MCF7 cells, suggesting that CNOT7 does not function solely in conjunction with BTG2. Further analysis of gene expression profiles of CNOT7 and/or CNOT8 knockdown cells underscores the partial redundancy between these subunits and suggests that regulation of several genes, including repression of the antiproliferative genes MSMB and PMP22, by the Ccr4-Not complex contributes to cell proliferation.</p>
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