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Article Dans Une Revue Drug Discovery Today Année : 2013

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

Résumé

The aryl hydrocarbon receptor (AhR) is a transcription factor which is activated by diverse compounds and regulates the expression of xenobiotic metabolism genes. Recent studies have unraveled unsuspected physiological roles and novel alternative ligand-specific pathways for this receptor. In this review, we discuss these novel aspects and focus on the different responses elicited by the diverse endogenous and/or exogenous AhR ligands. In addition to challenging the relevance of the 'agonist/antagonist' classification of ligands, we introduce the concept of AhR plasticity as a primordial factor in the generation of these pathways. Finally, we suggest several promising perspectives for the pharmacological modulation of these responses.
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hal-02190808 , version 1 (22-07-2019)

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Erwan Guyot, Aline Chevallier, Robert Barouki, Xavier Coumoul. The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications. Drug Discovery Today, 2013, 18 (9-10), pp.479-486. ⟨10.1016/j.drudis.2012.11.014⟩. ⟨hal-02190808⟩

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