Coupling Electrochemical Adsorption and Long‐range Electron Transfer: Label‐free DNA Mismatch Detection with Ultramicroelectrode (UME) - Archive ouverte HAL Access content directly
Journal Articles Electroanalysis Year : 2019

Coupling Electrochemical Adsorption and Long‐range Electron Transfer: Label‐free DNA Mismatch Detection with Ultramicroelectrode (UME)

Abstract

A new electrochemical hybridization trans-duction pathway, obtained by coupling electrochemical adsorption and long-range electron transfer through double-stranded DNA, was investigated using ultrami-croelectrode (UME). The results show that long-range electron transfer does not occurs exclusively throws well-packed and organized self-assembled DNA monolayers. This approach is used to investigate long-range electron transfer properties of both single-and double-stranded short synthetic DNA and DNA plasmids. Single mismatch electrochemical detection protocol of non-labelled short synthetic DNA, without heating or probe labelling, in a 10 minutes protocol, was in fine performed.
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Dates and versions

hal-02189989 , version 1 (20-07-2019)

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Nivedita Basu, Thu Huong Ho, François-Xavier Guillon, Yuanyuan Zhang, Pascal Bigey, et al.. Coupling Electrochemical Adsorption and Long‐range Electron Transfer: Label‐free DNA Mismatch Detection with Ultramicroelectrode (UME). Electroanalysis, 2019, 31 (11), pp.2232-2237. ⟨10.1002/elan.201900357⟩. ⟨hal-02189989⟩
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