Metal Ions and Complexes in Alzheimer's Disease: From Fundamental to Therapeutic Perspectives
Résumé
In this article, the author reviews the structural, thermodynamic, and kinetic data on metal ions (copper and zinc) binding to the amyloid‐β peptides of various sequences involved in Alzheimer's disease. Metal ions are indeed regarded as key players in Alzheimer's disease because they may contribute to the oxidative stress and modulate the aggregation propensity of the amyloid‐β peptides, two key processes in the etiology of the disease. An analogy with the influence of the interaction between metal ions and other intrinsically disordered peptides in different pathologies is also drawn. In a second part, several therapeutic and diagnostic approaches based on the role of metal ions are described and discussed. A selection of chelators, metallophores, prodrugs as well as inorganic compounds is proposed that illustrates the various strategies developed by inorganic medicinal chemists to fight Alzheimer's disease.
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Encyclopedia of Inorganic and Bioinorganic Chemistry.pdf (1.21 Mo)
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