<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02184965</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-13T09:26:08+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Send Orders for Reprints to reprints@benthamscience.ae Chronic Exposure to Low-level Cadmium in Diabetes: Role of Oxidative Stress and Comparison with Polychlorinated Biphenyls</title>
            <author role="aut">
              <persName>
                <forename type="first">Adeline</forename>
                <surname>Jacquet</surname>
              </persName>
              <idno type="halauthorid">1035783-0</idno>
              <affiliation ref="#struct-546388"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marine</forename>
                <surname>Lénon</surname>
              </persName>
              <idno type="idhal" notation="numeric">793273</idno>
              <idno type="halauthorid" notation="string">1422848-793273</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9567-2437</idno>
              <idno type="IDREF">https://www.idref.fr/280993269</idno>
              <affiliation ref="#struct-546388"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Josiane</forename>
                <surname>Arnaud</surname>
              </persName>
              <email type="md5">386fba43a2ce26172c9b2fb45a6303bd</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="numeric">836152</idno>
              <idno type="halauthorid" notation="string">174472-836152</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9101-3330</idno>
              <idno type="IDREF">https://www.idref.fr/14484446X</idno>
              <affiliation ref="#struct-34732"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Marc</forename>
                <surname>Moulis</surname>
              </persName>
              <email type="md5">a6bad16b3f23a83bdc61aad531d7cfdb</email>
              <email type="domain">cea.fr</email>
              <idno type="idhal" notation="numeric">1373779</idno>
              <idno type="halauthorid" notation="string">304015-1373779</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5615-9852</idno>
              <idno type="IDREF">https://www.idref.fr/060586605</idno>
              <affiliation ref="#struct-546388"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fayçal</forename>
                <surname>Ounnas</surname>
              </persName>
              <idno type="idhal" notation="numeric">788446</idno>
              <idno type="halauthorid" notation="string">1337196-788446</idno>
              <idno type="IDREF">https://www.idref.fr/168954710</idno>
              <affiliation ref="#struct-1042069"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patricia</forename>
                <surname>Salen</surname>
              </persName>
              <email type="md5">384387b32235e3c7c46aef7018813ce7</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="numeric">944045</idno>
              <idno type="halauthorid" notation="string">253123-944045</idno>
              <affiliation ref="#struct-1042069"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christine</forename>
                <surname>Demeilliers</surname>
              </persName>
              <email type="md5">fa57905b0efb4a276585fe533fa62d2a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">christine-demeilliers</idno>
              <idno type="idhal" notation="numeric">1199533</idno>
              <idno type="halauthorid" notation="string">1247437-1199533</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8648-4805</idno>
              <idno type="IDREF">https://www.idref.fr/060344458</idno>
              <idno type="VIAF">https://viaf.org/viaf/197788102</idno>
              <idno type="ISNI">http://isni.org/isni/0000000357458090</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/GWZ-9743-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/KQR-4072-2024</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/GWZ-9743-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/KQR-4072-2024</idno>
              <affiliation ref="#struct-546388"/>
              <affiliation ref="#struct-1042069"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luca</forename>
                <surname>Calani</surname>
              </persName>
              <idno type="halauthorid">1247434-0</idno>
              <affiliation ref="#struct-538908"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Francesca</forename>
                <surname>Scazzina</surname>
              </persName>
              <idno type="idhal" notation="numeric">793280</idno>
              <idno type="halauthorid" notation="string">1462146-793280</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5372-8658</idno>
              <affiliation ref="#struct-304135"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Hazane-Puch</surname>
              </persName>
              <idno type="halauthorid">785949-0</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Laporte</surname>
              </persName>
              <idno type="halauthorid">398688-0</idno>
              <affiliation ref="#struct-34732"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Camilla</forename>
                <surname>Melegari</surname>
              </persName>
              <idno type="halauthorid">1462147-0</idno>
              <affiliation ref="#struct-547482"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daniele</forename>
                <surname>del Rio</surname>
              </persName>
              <idno type="idhal" notation="numeric">784429</idno>
              <idno type="halauthorid" notation="string">1248044-784429</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5394-1259</idno>
              <idno type="IDREF">https://www.idref.fr/174771444</idno>
              <affiliation ref="#struct-538908"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>de Lorgeril</surname>
              </persName>
              <email type="md5">bbff3ab0ad64c86a0ad80d45f1a942f5</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="numeric">943451</idno>
              <idno type="halauthorid" notation="string">253071-943451</idno>
              <affiliation ref="#struct-1042069"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Christine</forename>
                <surname>Demeilliers</surname>
              </persName>
              <email type="md5">fa57905b0efb4a276585fe533fa62d2a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-07-16 12:44:26</date>
              <date type="whenModified">2026-03-26 16:30:05</date>
              <date type="whenReleased">2019-07-16 12:44:26</date>
              <date type="whenProduced">2016</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="757084">
                <persName>
                  <forename>Christine</forename>
                  <surname>Demeilliers</surname>
                </persName>
                <email type="md5">fa57905b0efb4a276585fe533fa62d2a</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02184965</idno>
            <idno type="halUri">https://hal.science/hal-02184965</idno>
            <idno type="halBibtex">jacquet:hal-02184965</idno>
            <idno type="halRefHtml">&lt;i&gt;Current Drug Targets&lt;/i&gt;, 2016, 17 (4), pp.1385 - 1413. &lt;a target="_blank" href="https://dx.doi.org/10.3109/09637486.2015.1024206"&gt;&amp;#x27E8;10.3109/09637486.2015.1024206&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Current Drug Targets, 2016, 17 (4), pp.1385 - 1413. &amp;#x27E8;10.3109/09637486.2015.1024206&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-PRETA" corresp="TIMC-IMAG">PRETA : Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</idno>
            <idno type="stamp" n="LBFA">Laboratoire de Bioénergétique Fondamentale et Appliquée</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-COMUE">Université Grenoble Alpes [2016-2019]</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Send Orders for Reprints to reprints@benthamscience.ae Chronic Exposure to Low-level Cadmium in Diabetes: Role of Oxidative Stress and Comparison with Polychlorinated Biphenyls</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Adeline</forename>
                    <surname>Jacquet</surname>
                  </persName>
                  <idno type="halauthorid">1035783-0</idno>
                  <affiliation ref="#struct-546388"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marine</forename>
                    <surname>Lénon</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">793273</idno>
                  <idno type="halauthorid" notation="string">1422848-793273</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9567-2437</idno>
                  <idno type="IDREF">https://www.idref.fr/280993269</idno>
                  <affiliation ref="#struct-546388"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Josiane</forename>
                    <surname>Arnaud</surname>
                  </persName>
                  <email type="md5">386fba43a2ce26172c9b2fb45a6303bd</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">836152</idno>
                  <idno type="halauthorid" notation="string">174472-836152</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9101-3330</idno>
                  <idno type="IDREF">https://www.idref.fr/14484446X</idno>
                  <affiliation ref="#struct-34732"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Marc</forename>
                    <surname>Moulis</surname>
                  </persName>
                  <email type="md5">a6bad16b3f23a83bdc61aad531d7cfdb</email>
                  <email type="domain">cea.fr</email>
                  <idno type="idhal" notation="numeric">1373779</idno>
                  <idno type="halauthorid" notation="string">304015-1373779</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5615-9852</idno>
                  <idno type="IDREF">https://www.idref.fr/060586605</idno>
                  <affiliation ref="#struct-546388"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fayçal</forename>
                    <surname>Ounnas</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">788446</idno>
                  <idno type="halauthorid" notation="string">1337196-788446</idno>
                  <idno type="IDREF">https://www.idref.fr/168954710</idno>
                  <affiliation ref="#struct-1042069"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patricia</forename>
                    <surname>Salen</surname>
                  </persName>
                  <email type="md5">384387b32235e3c7c46aef7018813ce7</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">944045</idno>
                  <idno type="halauthorid" notation="string">253123-944045</idno>
                  <affiliation ref="#struct-1042069"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christine</forename>
                    <surname>Demeilliers</surname>
                  </persName>
                  <email type="md5">fa57905b0efb4a276585fe533fa62d2a</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">christine-demeilliers</idno>
                  <idno type="idhal" notation="numeric">1199533</idno>
                  <idno type="halauthorid" notation="string">1247437-1199533</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8648-4805</idno>
                  <idno type="IDREF">https://www.idref.fr/060344458</idno>
                  <idno type="VIAF">https://viaf.org/viaf/197788102</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000357458090</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/GWZ-9743-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/KQR-4072-2024</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/GWZ-9743-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/KQR-4072-2024</idno>
                  <affiliation ref="#struct-546388"/>
                  <affiliation ref="#struct-1042069"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luca</forename>
                    <surname>Calani</surname>
                  </persName>
                  <idno type="halauthorid">1247434-0</idno>
                  <affiliation ref="#struct-538908"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Francesca</forename>
                    <surname>Scazzina</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">793280</idno>
                  <idno type="halauthorid" notation="string">1462146-793280</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5372-8658</idno>
                  <affiliation ref="#struct-304135"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Hazane-Puch</surname>
                  </persName>
                  <idno type="halauthorid">785949-0</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Laporte</surname>
                  </persName>
                  <idno type="halauthorid">398688-0</idno>
                  <affiliation ref="#struct-34732"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Camilla</forename>
                    <surname>Melegari</surname>
                  </persName>
                  <idno type="halauthorid">1462147-0</idno>
                  <affiliation ref="#struct-547482"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daniele</forename>
                    <surname>del Rio</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">784429</idno>
                  <idno type="halauthorid" notation="string">1248044-784429</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5394-1259</idno>
                  <idno type="IDREF">https://www.idref.fr/174771444</idno>
                  <affiliation ref="#struct-538908"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>de Lorgeril</surname>
                  </persName>
                  <email type="md5">bbff3ab0ad64c86a0ad80d45f1a942f5</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">943451</idno>
                  <idno type="halauthorid" notation="string">253071-943451</idno>
                  <affiliation ref="#struct-1042069"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12247</idno>
                <idno type="issn">1389-4501</idno>
                <title level="j">Current Drug Targets</title>
                <imprint>
                  <publisher>Bentham Science Publishers</publisher>
                  <biblScope unit="volume">17</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">1385 - 1413</biblScope>
                  <date type="datePub">2016</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3109/09637486.2015.1024206</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">risk assessment</term>
                <term xml:lang="en">biomarkers</term>
                <term xml:lang="en">low dose</term>
                <term xml:lang="en">polychlorinated biphenyl compounds (PCB)</term>
                <term xml:lang="en">oxidative stress</term>
                <term xml:lang="en">insulin</term>
                <term xml:lang="en">diabetes</term>
                <term xml:lang="en">Cadmium</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.tox">Life Sciences [q-bio]/Toxicology</classCode>
              <classCode scheme="halDomain" n="sdv.aen">Life Sciences [q-bio]/Food and Nutrition</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Among the most important physiological functions, maintenance of the oxidation reduction equilibrium in cells stands out as a major homeostatic event. Many environmental contaminants efficiently trap cellular reducing compounds, but the actual importance of this mode of toxicity is far from being precisely known. This statement applies to cases of slowly developing chronic diseases, such as neuro-degenerations, diabetes, and many others. The involvement of oxidative challenge in diabetes is considered in connection with chronic dietary exposure to low-level concentrations of cadmium. Comparison is made with polychlorobiphenyl molecules (PCB): they are structurally unrelated to cadmium, they preferentially distribute into different organs than cadmium, and they follow different metabolic pathways. Yet, they have also pro-oxidative properties, and they are associated with diabetes. Since neither cadmium nor PCB is a direct oxidant, they both follow indirect pathways to shift the redox equilibrium. Thus, a difference must be made between the adaptable response of the organism, i.e. the anti-oxidant response, and the irreversible damage generated by oxidizing species, i.e. oxidative damage, when exposure occurs at low concentrations. The approximate border between high and low levels of exposure is estimated in this review from the available relevant data, and the strengths and weaknesses of experimental models are delineated. Eventually, chronic low level exposure to these contaminants sparks cellular responses setting ground for dysfunction and disease, such as diabetes: oxidative damage is an accompanying phenomenon and not necessarily an early mechanism of toxicity.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-546388" status="OLD">
          <idno type="IdRef">184930839</idno>
          <idno type="RNSR">201119430B</idno>
          <orgName>Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée</orgName>
          <orgName type="acronym">LBFA</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Bâtiment B Biologie, 2280 Rue de la Piscine, 38400 Saint Martin d'Hères</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://lbfa.univ-grenoble-alpes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1055" active="#struct-303623" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-34732" status="VALID">
          <orgName>Département de biologie intégrée</orgName>
          <desc>
            <address>
              <addrLine>Grenoble</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-257328" type="direct"/>
            <relation active="#struct-300199" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1042069" status="OLD">
          <orgName>Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</orgName>
          <orgName type="acronym">TIMC-IMAG-PRETA</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/preta</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042061" type="direct"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-445543" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-538908" status="INCOMING">
          <orgName>Department of Food Science, Human Nutrition Unit, The Phi² Laboratory of Phytochemicals in Physiology - LS9 Bioactives and Health, Interlab Group</orgName>
          <desc>
            <address>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-304135" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-304135" status="VALID">
          <idno type="IdRef">026486466</idno>
          <orgName>Università degli studi di Parma = University of Parma</orgName>
          <orgName type="acronym">UNIPR</orgName>
          <date type="start">0962-01-01</date>
          <desc>
            <address>
              <addrLine>via Università, 12 - I 43121 Parma</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.unipr.it</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-547482" status="INCOMING">
          <orgName>Barilla, Parma</orgName>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-445543" status="OLD">
          <idno type="IdRef">188399275</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes [2016-2019]</orgName>
          <orgName type="acronym">UGA [2016-2019]</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300199" status="VALID">
          <orgName>Hôpital Michallon</orgName>
          <desc>
            <address>
              <addrLine>CHU Grenoble-Alpes</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1042061" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>