As part of its expanding role, particularly as an agent of peace building, the United Nations (UN) actively participates in the implementation of measures to prevent and manage crisis/disaster situations. The purpose of such an approach is to empower the victims, protect the environment, rebuild communities, and create employment. However, real world crisis management situations are complex given the multiple interrelated interests, actors, relations, and objectives. Recent studies in healthcare contexts, which also have dynamic and complex operations, have shown the merit and benefits of employing various tools and techniques from the domain of knowledge management (KM). Hence, this paper investigates three distinct natural crisis situations (the 2010 Haiti Earthquake, the 2004 Boxing Day Asian Tsunami, and the 2001 Gujarat Earthquake) with which the United Nations and international aid agencies have been and are currently involved, to identify recurring issues which continue to provide knowledge-based impediments. Major findings from each case study are analyzed according to the estimated impact of identified impediments. The severity of the enumerated knowledge-based issues is quantified and compared by means of an assigned qualitative to identify the most significant attribute.