Membrane lectins on human monocytes. Maturation-dependent modulation of 6-phosphomannose and mannose receptors. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 1985

Membrane lectins on human monocytes. Maturation-dependent modulation of 6-phosphomannose and mannose receptors.

Patrick Midoux
Philippe Bouchard

Résumé

Freshly isolated human monocytes, which do not contain cell-surface mannose-specific receptors, bind mannose 6-phosphate and actively endocytose mannose 6-phosphate-bearing neoglycoproteins (6-P-Man-F-BSA). Three days after isolation, human monocytes endocytose very actively 6-P-Man-F-BSA as well as Man-F-BSA, and the endocytosed neoglycoproteins are rapidly degraded. These results were obtained in quantitative flow cytofluorometry by using a panel of fluoresceinylated sugar-substituted serum albumins (neoglycoproteins). Thus, in contrast to mannose receptors which appear only after maturation, mannose 6-phosphate receptors are already present on freshly isolated human monocytes.
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Dates et versions

hal-02163594 , version 1 (24-06-2019)

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Annie-Claude Roche, Patrick Midoux, Philippe Bouchard, Michel Monsigny. Membrane lectins on human monocytes. Maturation-dependent modulation of 6-phosphomannose and mannose receptors.. FEBS Letters, 1985, 193 (1), pp.63-68. ⟨10.1016/0014-5793(85)80080-6⟩. ⟨hal-02163594⟩
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