Stochastic Gene Expression with a Multistate Promoter: Breaking Down Exact Distributions - Archive ouverte HAL
Article Dans Une Revue SIAM Journal on Applied Mathematics Année : 2019

Stochastic Gene Expression with a Multistate Promoter: Breaking Down Exact Distributions

Résumé

We consider a stochastic model of gene expression in which transcription depends on a multistate promoter, including the famous two-state model and refractory promoters as special cases, and focus on deriving the exact stationary distribution. Building upon several successful approaches, we present a more unified viewpoint that enables us to simplify and generalize existing results. In particular, the original jump process is deeply related to a multivariate piecewise-deterministic Markov process that may also be of interest beyond the biological field. In a very particular case of promoter configuration, this underlying process is shown to have a simple Dirichlet stationary distribution. In the general case, the corresponding marginal distributions extend the well-known class of Beta products, involving complex parameters that directly relate to spectral properties of the promoter transition matrix. Finally, we illustrate these results with biologically plausible examples.

Dates et versions

hal-02159699 , version 1 (18-06-2019)

Identifiants

Citer

Ulysse Herbach. Stochastic Gene Expression with a Multistate Promoter: Breaking Down Exact Distributions. SIAM Journal on Applied Mathematics, 2019, 79 (3), pp.1007-1029. ⟨10.1137/18M1181006⟩. ⟨hal-02159699⟩
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