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Article Dans Une Revue Annals of Intensive Care Année : 2019

Formal guidelines: management of acute respiratory distress syndrome

Claude Guérin
Armand Mekontso-Dessap
Alain Mercat
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Damien Roux
Antoine Vieillard-Baron

Résumé

Fifteen recommendations and a therapeutic algorithm regarding the management of acute respiratory distress syndrome (ARDS) at the early phase in adults are proposed. The Grade of Recommendation Assessment, Development and Evaluation (GRADE) methodology has been followed. Four recommendations (low tidal volume, plateau pressure limitation, no oscillatory ventilation, and prone position) had a high level of proof (GRADE 1 + or 1 -); four (high positive end-expiratory pressure [PEEP] in moderate and severe ARDS, muscle relaxants, recruitment maneuvers, and venovenous extracorporeal membrane oxygenation [ECMO]) a low level of proof (GRADE 2 + or 2 -); seven (surveillance, tidal volume for non ARDS mechanically ventilated patients, tidal volume limitation in the presence of low plateau pressure, PEEP > 5 cmH2O, high PEEP in the absence of deleterious effect, pressure mode allowing spontaneous ventilation after the acute phase, and nitric oxide) corresponded to a level of proof that did not allow use of the GRADE classification and were expert opinions. Lastly, for three aspects of ARDS management (driving pressure, early spontaneous ventilation, and extracorporeal carbon dioxide removal), the experts concluded that no sound recommendation was possible given current knowledge. The recommendations and the therapeutic algorithm were approved by the experts with strong agreement.
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Dates et versions

hal-02157110 , version 1 (17-06-2020)

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Laurent Papazian, Cecile Aubron, Laurent J. Brochard, Jean-Daniel Chiche, Alain Combes, et al.. Formal guidelines: management of acute respiratory distress syndrome. Annals of Intensive Care, 2019, 9 (1), pp.69. ⟨10.1186/s13613-019-0540-9⟩. ⟨hal-02157110⟩
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