In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Aging Neuroscience Year : 2016

In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy

(1) , (2) , (2) , (3) , (3) , (4) , (5, 2) , (6) , (7)
1
2
3
4
5
6
7

Abstract

Extracellular deposition of β amyloid plaques is an early event associated to Alzheimer's disease. Here, we have used in vivo gadolinium-stained high resolution (29 * 29 * 117 µm 3) magnetic resonance imaging (MRI) to follow-up in a longitudinal way individual amyloid plaques in APP/PS1 mice and evaluate the efficacy of a new immunotherapy (SAR255952) directed against protofibrillar and fibrillary forms of Aβ. APP/PS1 mice were treated for 5 months between the age of 3.5 and 8.5 months. SAR255952 reduced amyloid load in 8.5-months-old animals, but not in 5.5-months animals compared to mice treated with a control antibody (DM4). Histological evaluation confirmed the reduction of amyloid load and revealed a lower density of amyloid plaques in 8.5-months SAR255952-treated animals. The longitudinal follow-up of individual amyloid plaques by MRI revealed that plaques that were visible at 5.5 months were still visible at 8.5 months in both SAR255952 and DM4-treated mice. This suggests that the amyloid load reduction induced by SAR255952 is related to a slowing down in the formation of new plaques rather than to the clearance of already formed plaques.
Fichier principal
Vignette du fichier
santin2016fnagi.pdf (1.62 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02155734 , version 1 (13-06-2019)

Identifiers

Cite

Mathieu D. Santin, Michel Vandenberghe, Anne-Sophie Herard, Laurent Pradier, Caroline Cohen, et al.. In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy. Frontiers in Aging Neuroscience, 2016, 8, ⟨10.3389/fnagi.2016.00055⟩. ⟨hal-02155734⟩
146 View
25 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More