<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02155726</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T16:47:01+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease</title>
            <author role="aut">
              <persName>
                <forename type="first">Géraldine</forename>
                <surname>Poisnel</surname>
              </persName>
              <idno type="halauthorid">1232343-0</idno>
              <affiliation ref="#struct-519275"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne-Sophie</forename>
                <surname>Herard</surname>
              </persName>
              <email type="md5">c0af55389d876782fbf2212d25e6d351</email>
              <email type="domain">cea.fr</email>
              <idno type="idhal" notation="string">anne-sophie-herard</idno>
              <idno type="idhal" notation="numeric">175012</idno>
              <idno type="halauthorid" notation="string">35702-175012</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-5838-2013</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8260-9618</idno>
              <idno type="IDREF">https://www.idref.fr/253125839</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-5838-2013</idno>
              <affiliation ref="#struct-93273"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadine</forename>
                <surname>El Tannir El Tayara</surname>
              </persName>
              <idno type="halauthorid">1148830-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuel</forename>
                <surname>Bourrin</surname>
              </persName>
              <idno type="halauthorid">1603117-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Andreas</forename>
                <surname>Volk</surname>
              </persName>
              <idno type="halauthorid">1603118-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frank</forename>
                <surname>Kober</surname>
              </persName>
              <email type="md5">9e26e4a340974b3a69fc2eaca4139dcb</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">frank-kober</idno>
              <idno type="idhal" notation="numeric">174796</idno>
              <idno type="halauthorid" notation="string">402804-174796</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7869-3615</idno>
              <idno type="IDREF">https://www.idref.fr/175062366</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/L-8737-2013</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/L-8737-2013</idno>
              <affiliation ref="#struct-480402"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoit</forename>
                <surname>Delatour</surname>
              </persName>
              <idno type="halauthorid">989875-0</idno>
              <affiliation ref="#struct-246044"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thierry</forename>
                <surname>Delzescaux</surname>
              </persName>
              <idno type="halauthorid">578527-0</idno>
              <affiliation ref="#struct-93273"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Debeir</surname>
              </persName>
              <idno type="halauthorid">208296-0</idno>
              <affiliation ref="#struct-3037"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Rooney</surname>
              </persName>
              <idno type="halauthorid">737977-0</idno>
              <affiliation ref="#struct-92706"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jesus</forename>
                <forename type="middle">J</forename>
                <surname>Benavides</surname>
              </persName>
              <idno type="halauthorid">1109809-0</idno>
              <affiliation ref="#struct-92706"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Hantraye</surname>
              </persName>
              <idno type="halauthorid">170679-0</idno>
              <affiliation ref="#struct-93273"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Dhenain</surname>
              </persName>
              <email type="md5">655bf982ed3257e32bfb3dcd73a452bc</email>
              <email type="domain">cnrs.fr</email>
              <idno type="idhal" notation="string">marc-dhenain</idno>
              <idno type="idhal" notation="numeric">180107</idno>
              <idno type="halauthorid" notation="string">7847-180107</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-5630-2013</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8804-4101</idno>
              <idno type="IDREF">https://www.idref.fr/157985458</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-5630-2013</idno>
              <affiliation ref="#struct-93273"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Anne-Sophie</forename>
                <surname>Hérard</surname>
              </persName>
              <email type="md5">c0af55389d876782fbf2212d25e6d351</email>
              <email type="domain">cea.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-05-25 13:11:38</date>
              <date type="whenModified">2025-09-29 13:18:10</date>
              <date type="whenReleased">2021-05-25 13:12:37</date>
              <date type="whenProduced">2012-09</date>
              <date type="whenEndEmbargoed">2021-05-25</date>
              <ref type="file" target="https://hal.science/hal-02155726v1/document">
                <date notBefore="2021-05-25"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-02155726v1/file/2012BDelatour_Increased%20regional%20cerebral.pdf" id="file-3234534-2840038">
                <date notBefore="2021-05-25"/>
              </ref>
              <ref type="externalLink" target="http://europepmc.org/articles/pmc3666917?pdf=render"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="722028">
                <persName>
                  <forename>Anne-Sophie</forename>
                  <surname>Hérard</surname>
                </persName>
                <email type="md5">c0af55389d876782fbf2212d25e6d351</email>
                <email type="domain">cea.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02155726</idno>
            <idno type="halUri">https://hal.science/hal-02155726</idno>
            <idno type="halBibtex">poisnel:hal-02155726</idno>
            <idno type="halRefHtml">&lt;i&gt;Neurobiology of Aging&lt;/i&gt;, 2012, 33 (9), pp.1995-2005. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.neurobiolaging.2011.09.026"&gt;&amp;#x27E8;10.1016/j.neurobiolaging.2011.09.026&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Neurobiology of Aging, 2012, 33 (9), pp.1995-2005. &amp;#x27E8;10.1016/j.neurobiolaging.2011.09.026&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3234534-2840038"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CRMBM">Centre de Résonance Magnétique Biologique et Médicale</idno>
            <idno type="stamp" n="ICM" corresp="SORBONNE-UNIVERSITE">Institut du Cerveau et de la Moëlle Epinière</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="UPMC_POLE_4" corresp="UPMC">UPMC Pôle 4</idno>
            <idno type="stamp" n="JACOB" corresp="CEA">Institut de Biologie François JACOB</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="UNICAEN">Université de Caen Normandie</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="MIRCEN" corresp="CEA">Molecular Imaging Research Center</idno>
            <idno type="stamp" n="SU-INF-2018" corresp="SORBONNE-UNIVERSITE">SORBONNE université &lt;2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Géraldine</forename>
                    <surname>Poisnel</surname>
                  </persName>
                  <idno type="halauthorid">1232343-0</idno>
                  <affiliation ref="#struct-519275"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne-Sophie</forename>
                    <surname>Herard</surname>
                  </persName>
                  <email type="md5">c0af55389d876782fbf2212d25e6d351</email>
                  <email type="domain">cea.fr</email>
                  <idno type="idhal" notation="string">anne-sophie-herard</idno>
                  <idno type="idhal" notation="numeric">175012</idno>
                  <idno type="halauthorid" notation="string">35702-175012</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-5838-2013</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8260-9618</idno>
                  <idno type="IDREF">https://www.idref.fr/253125839</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-5838-2013</idno>
                  <affiliation ref="#struct-93273"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadine</forename>
                    <surname>El Tannir El Tayara</surname>
                  </persName>
                  <idno type="halauthorid">1148830-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuel</forename>
                    <surname>Bourrin</surname>
                  </persName>
                  <idno type="halauthorid">1603117-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Andreas</forename>
                    <surname>Volk</surname>
                  </persName>
                  <idno type="halauthorid">1603118-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frank</forename>
                    <surname>Kober</surname>
                  </persName>
                  <email type="md5">9e26e4a340974b3a69fc2eaca4139dcb</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">frank-kober</idno>
                  <idno type="idhal" notation="numeric">174796</idno>
                  <idno type="halauthorid" notation="string">402804-174796</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7869-3615</idno>
                  <idno type="IDREF">https://www.idref.fr/175062366</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/L-8737-2013</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/L-8737-2013</idno>
                  <affiliation ref="#struct-480402"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoit</forename>
                    <surname>Delatour</surname>
                  </persName>
                  <idno type="halauthorid">989875-0</idno>
                  <affiliation ref="#struct-246044"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thierry</forename>
                    <surname>Delzescaux</surname>
                  </persName>
                  <idno type="halauthorid">578527-0</idno>
                  <affiliation ref="#struct-93273"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Debeir</surname>
                  </persName>
                  <idno type="halauthorid">208296-0</idno>
                  <affiliation ref="#struct-3037"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Rooney</surname>
                  </persName>
                  <idno type="halauthorid">737977-0</idno>
                  <affiliation ref="#struct-92706"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jesus</forename>
                    <forename type="middle">J</forename>
                    <surname>Benavides</surname>
                  </persName>
                  <idno type="halauthorid">1109809-0</idno>
                  <affiliation ref="#struct-92706"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Hantraye</surname>
                  </persName>
                  <idno type="halauthorid">170679-0</idno>
                  <affiliation ref="#struct-93273"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Dhenain</surname>
                  </persName>
                  <email type="md5">655bf982ed3257e32bfb3dcd73a452bc</email>
                  <email type="domain">cnrs.fr</email>
                  <idno type="idhal" notation="string">marc-dhenain</idno>
                  <idno type="idhal" notation="numeric">180107</idno>
                  <idno type="halauthorid" notation="string">7847-180107</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-5630-2013</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8804-4101</idno>
                  <idno type="IDREF">https://www.idref.fr/157985458</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-5630-2013</idno>
                  <affiliation ref="#struct-93273"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17371</idno>
                <idno type="issn">0197-4580</idno>
                <title level="j">Neurobiology of Aging</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">33</biblScope>
                  <biblScope unit="issue">9</biblScope>
                  <biblScope unit="pp">1995-2005</biblScope>
                  <date type="datePub">2012-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.neurobiolaging.2011.09.026</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Alzheimer</term>
                <term xml:lang="en">Amyloid</term>
                <term xml:lang="en">Biomarker</term>
                <term xml:lang="en">Cerebral glucose uptake</term>
                <term xml:lang="en">[14C]-2-deoxyglucose</term>
                <term xml:lang="en">[18F]-FDG-PET</term>
                <term xml:lang="en">APP/PS1 transgenic mice</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is characterized by the invariant cerebral accumulation of ␤-amyloid peptide. This event occurs early in the disease process. In humans, [18F]-fluoro-2-deoxy-D-glucose ([18F]-FDG) positron emission tomography (PET) is largely used to follow-up in vivo cerebral glucose utilization (CGU) and brain metabolism modifications associated with the Alzheimer's disease pathology. Here, [18F]-FDG positron emission tomography was used to study age-related changes of cerebral glucose utilization under resting conditions in 3-, 6-, and 12-month-old APP SweLon /PS1 M146L , a mouse model of amyloidosis. We showed an age-dependent increase of glucose uptake in several brain regions of APP/PS1 mice but not in control animals and a higher [18F]-FDG uptake in the cortex and the hippocampus of 12-month-old APP/PS1 mice as compared with age-matched control mice. We then developed a method of 3-D microscopic autoradiography to evaluate glucose uptake at the level of amyloid plaques and showed an increased glucose uptake close to the plaques rather than in amyloid-free cerebral tissues. These data suggest a macroscopic and microscopic reorganization of glucose uptake in relation to cerebral amyloidosis.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-519275" status="VALID">
          <idno type="IdRef">185204619</idno>
          <idno type="RNSR">201722477M</idno>
          <idno type="ROR">https://ror.org/00vsvph51</idno>
          <idno type="Wikidata">Q121599431</idno>
          <orgName>Physiopathologie et imagerie des troubles neurologiques</orgName>
          <orgName type="acronym">PhIND</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>GIP Cyceron, Boulevard Becquerel, 14074 Caen cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.phind.fr/index.php/en/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7127" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation name="U1237" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-93273" status="VALID">
          <idno type="RNSR">201521304W</idno>
          <idno type="ROR">00az7j379</idno>
          <orgName>Laboratoire des Maladies Neurodégénératives - UMR 9199</orgName>
          <orgName type="acronym">LMN</orgName>
          <desc>
            <address>
              <addrLine>18 Route du panorama CEA Fontenay-aux-Roses Bâtiment 61 92 265 Fontenay-aux-Roses CEDEX Tel : 00 33 (0)1 46 54 84 11</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/UMR9199.aspx</ref>
          </desc>
          <listRelation>
            <relation name="DRF/JACOB" active="#struct-40416" type="direct"/>
            <relation active="#struct-419361" type="indirect"/>
            <relation active="#struct-441569" type="direct"/>
            <relation name="DRF/JACOB/MIRCEN" active="#struct-487601" type="indirect"/>
            <relation name="DRF/JACOB" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation name="UMR9199" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-480402" status="VALID">
          <idno type="IdRef">122901924</idno>
          <idno type="RNSR">201220246J</idno>
          <idno type="ROR">https://ror.org/04ceg1205</idno>
          <orgName>Centre de résonance magnétique biologique et médicale</orgName>
          <orgName type="acronym">CRMBM</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine27 Bd Jean Moulin 13385 MARSEILLE CEDEX 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crmbm.univ-amu.fr/?lang=fr</ref>
          </desc>
          <listRelation>
            <relation name="UMR7339" active="#struct-198056" type="direct"/>
            <relation name="UMR7339" active="#struct-300073" type="direct"/>
            <relation name="UMR7339" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-246044" status="OLD">
          <idno type="RNSR">200918525B</idno>
          <orgName>Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute</orgName>
          <orgName type="acronym">ICM</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UM75" active="#struct-93591" type="direct"/>
            <relation name="U1127" active="#struct-303623" type="direct"/>
            <relation active="#struct-353778" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation active="#struct-413221" type="indirect"/>
            <relation name="UMR7225" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-3037" status="OLD">
          <orgName>Neurologie et thérapeutique expérimentale</orgName>
          <desc>
            <address>
              <addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93591" type="direct"/>
            <relation active="#struct-300636" type="direct"/>
            <relation name="U679" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-92706" status="VALID">
          <orgName>Sanofi-Aventis R&amp;D</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300501" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-7127" status="VALID">
          <idno type="IdRef">026403064</idno>
          <idno type="ISNI">0000000121864076</idno>
          <idno type="ROR">https://ror.org/051kpcy16</idno>
          <orgName>Université de Caen Normandie</orgName>
          <orgName type="acronym">UNICAEN</orgName>
          <date type="start">1432-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-40416" status="VALID">
          <idno type="RNSR">201722559B</idno>
          <orgName>Molecular Imaging Research Center [Fontenay-aux-Roses]</orgName>
          <orgName type="acronym">MIRCEN</orgName>
          <desc>
            <address>
              <addrLine>Fontenay-aux-Roses</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen.aspx</ref>
          </desc>
          <listRelation>
            <relation active="#struct-419361" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
            <relation name="DRF/JACOB/MIRCEN" active="#struct-487601" type="direct"/>
            <relation name="DRF/JACOB" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-487601" status="VALID">
          <idno type="IdRef">188444645</idno>
          <idno type="RNSR">201722499L</idno>
          <idno type="Wikidata">Q122948322</idno>
          <orgName>Institut de Biologie François JACOB</orgName>
          <orgName type="acronym">JACOB</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>DRFCEAFontenay-aux-Roses</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="DRF/JACOB" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
          <desc>
            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-93591" status="OLD">
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.upmc.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-353778" status="VALID">
          <idno type="ROR">https://ror.org/02mh9a093</idno>
          <orgName>CHU Pitié-Salpêtrière [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300636" status="VALID">
          <orgName>IFR70</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300501" status="VALID">
          <orgName>SANOFI Recherche</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>