Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2010

Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas

Résumé

Brain glucose uptake was examined in transgenic mice relevant to Alzheimer's disease (APP/PS1) and their control littermates (PS1). Glucose distribution in the brain of the resting animals was measured using 3D-reconstructed autoradiography and analysed by a voxel-wise approach using SPMMouse combined to an MRI-based 3D digital atlas. Prompt and direct indexation of metabolic changes between the two groups was achieved, showing both hypo-and hypermetabolism of glucose in the brain of APP/PS1 mice. We confirm and extend previous study, since we identified brain structures affected in this pathological model and demonstrate glucose uptake changes in structures like the olfactory bulb. Our results pave the way to complete and accurate examination of functional data from cerebral structures involved in models of neurodegenerative diseases.
Fichier principal
Vignette du fichier
lebenberg2010ieeeembs.pdf (475.45 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02155722 , version 1 (13-06-2019)

Identifiants

Citer

Jessica Lebenberg, Anne-Sophie Herard, Albertine Dubois, Marc Dhenain, Philippe Hantraye, et al.. Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas. 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010), Aug 2010, Buenos Aires, Argentina. pp.5636-5639, ⟨10.1109/IEMBS.2010.5628043⟩. ⟨hal-02155722⟩
23 Consultations
116 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More