The signature of westward propagating mesoscale eddies in sea surface salinity (SSS) is analyzed for the tropical Pacific by collocating 7 years (2010–2016) of Soil Moisture and Ocean Salinity SSS satellite data with coherent mesoscale eddies automatically identified and tracked from altimetry‐derived sea level anomalies. First, the main characteristics of the long‐lived coherent eddies are inferred from sea level anomalies maps. Then, the mean signature of the mesoscale eddies on SSS is depicted for the whole tropical Pacific before focusing in regions centered around the central and eastern parts of the tropical North Pacific. In these areas, composite analyses based on thousands of eddies reveal regionally dependent eddy impacts with opposite SSS anomalies for cyclonic and anticyclonic eddies. In the central region, where the largest meridional SSS large‐scale gradients and smallest eddy amplitudes are observed, results show dipole‐like SSS changes with maximum anomalies on the leading edge of the composite eddy. In contrast, in the eastern region, where the largest near‐surface vertical salinity gradients and largest eddy amplitudes are observed, the composite eddy shows monopole‐like SSS changes with maximum anomalies near the composite eddy center. These distinct dipole/monopole SSS patterns suggest the dominant role of horizontal advection and vertical processes in the central and eastern regions, respectively. Other possible explanations, notably one involving the contrasted eddy amplitudes of the two regions, are discussed.