Planar Chiral Phosphoramidites with a Paracyclophane Scaffold: Synthesis, Gold(I) Complexes, and Enantioselective Cycloisomerization of Dienynes
Résumé
The key structuralf eature of the new phosphor-amidites is ap aracyclophane scaffoldi nw hich two aryl rings are tethered by both a1 ,8-biphenylene unit and aO ÀPÀOb ridge. Suitable aryl substituents generate planar chirality.T he corresponding gold(I) complexes promote the cycloisomerization of prochiral nitrogen-tethered dienynes. These reactions afford bicyclo[4.1.0]hep-tene derivatives displaying three contiguous stereogenic centers, with very high diastereoselectivity and up to 95 % ee.
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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