Silyl-Substituted Planar Chiral Phosphoric Acids with Ferrocene-bridged Paracyclophane Frameworks: Synthesis, Characterization, and Uses in Enantioselective aza-Friedel-Crafts Reactions - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2017

Silyl-Substituted Planar Chiral Phosphoric Acids with Ferrocene-bridged Paracyclophane Frameworks: Synthesis, Characterization, and Uses in Enantioselective aza-Friedel-Crafts Reactions

Résumé

This manuscript reports on a suitable method for the synthesis of paracyclophane type, ferrocene-bridged chiral phosphoric acids, which bear silyl-substituents on their paracyclophane frameworks. These acids have been obtained easily in enantiomerically pure form, by taking advantage of (S)-(1-phenyl-2-cyanoethyl)phosphorodiamidite as a phosphorylating agent. They have been used then as catalysts for aza-Friedel-Crafts reactions between indoles and imines, giving high catalytic activity and up to 98% enantiomeric excess.
Fichier principal
Vignette du fichier
32 2017 ASC Silyl-Substituted Planar Chiral Phosphoric Acids with Ferrocene-bridged Paracyclophane Frameworks OK.pdf (3.29 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02152293 , version 1 (11-06-2019)

Identifiants

Citer

Jérémy Stemper, Kevin Isaac, Nayan Ghosh, Hortense Lauwick, Gaëtan Le duc, et al.. Silyl-Substituted Planar Chiral Phosphoric Acids with Ferrocene-bridged Paracyclophane Frameworks: Synthesis, Characterization, and Uses in Enantioselective aza-Friedel-Crafts Reactions. Advanced Synthesis and Catalysis, 2017, 359 (3), pp.519-526. ⟨10.1002/adsc.201600920⟩. ⟨hal-02152293⟩
98 Consultations
81 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More