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Journal Articles Nucleic Acids Research Year : 2019

PLZF limits enhancer activity during hematopoietic progenitor aging

Abstract

PLZF (promyelocytic leukemia zinc finger) is a transcription factor acting as a global regulator of hematopoietic commitment. PLZF displays an epige-netic specificity by recruiting chromatin-modifying factors but little is known about its role in remod-eling chromatin of cells committed toward a given specific hematopoietic lineage. In murine myeloid progenitors, we decipher a new role for PLZF in restraining active genes and enhancers by targeting acetylated lysine 27 of Histone H3 (H3K27ac). Functional analyses reveal that active enhancers bound by PLZF are involved in biological processes related to metabolism and associated with hematopoietic aging. Comparing the epigenome of young and old myeloid progenitors, we reveal that H3K27ac variation at active enhancers is a hallmark of hematopoi-etic aging. Taken together, these data suggest that PLZF, associated with active enhancers, appears to restrain their activity as an epigenetic gatekeeper of hematopoietic aging.
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Dates and versions

hal-02145730 , version 1 (03-06-2019)

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Mathilde Poplineau, Julien Vernerey, Nadine Platet, Lia N'Guyen, Léonard Hérault, et al.. PLZF limits enhancer activity during hematopoietic progenitor aging. Nucleic Acids Research, 2019, 47 (9), pp.4509-4520. ⟨10.1093/nar/gkz174⟩. ⟨hal-02145730⟩
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