<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02143190</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-04-23T13:55:36+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Whole-genome sequencing of Aspergillus tubingensis G131 and overview of its secondary metabolism potential</title>
            <author role="aut">
              <persName>
                <forename type="first">Élodie</forename>
                <surname>Choque</surname>
              </persName>
              <email type="md5">f12294d35673fa5c7961be0e628bda12</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="numeric">1151835</idno>
              <idno type="halauthorid" notation="string">1497992-1151835</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5261-0738</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CLS-0773-2022</idno>
              <idno type="IDREF">https://www.idref.fr/16652882X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CLS-0773-2022</idno>
              <affiliation ref="#struct-509622"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Klopp</surname>
              </persName>
              <email type="md5">f93857cbb1e31166591501eb948338d3</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">0000-0001-7126-5477</idno>
              <idno type="idhal" notation="numeric">735911</idno>
              <idno type="halauthorid" notation="string">2518060-735911</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7126-5477</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-92114"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Valiere</surname>
              </persName>
              <email type="md5">ca3a84271452ef50e0d4455114077fb1</email>
              <email type="domain">toulouse.inra.fr</email>
              <idno type="idhal" notation="string">sophie-valiere</idno>
              <idno type="idhal" notation="numeric">1203291</idno>
              <idno type="halauthorid" notation="string">1237166-1203291</idno>
              <idno type="ORCID">https://orcid.org/0009-0000-3430-7164</idno>
              <affiliation ref="#struct-92114"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">José</forename>
                <surname>Raynal</surname>
              </persName>
              <idno type="halauthorid">893754-0</idno>
              <affiliation ref="#struct-437012"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Mathieu</surname>
              </persName>
              <email type="md5">7bc5b46b1f1552021a22c030ef910270</email>
              <email type="domain">toulouse-inp.fr</email>
              <idno type="idhal" notation="string">florence-mathieu</idno>
              <idno type="idhal" notation="numeric">766766</idno>
              <idno type="halauthorid" notation="string">655049-766766</idno>
              <idno type="IDREF">https://www.idref.fr/12722887X</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3071-9561</idno>
              <idno type="VIAF">https://viaf.org/viaf/306435508</idno>
              <idno type="ISNI">http://isni.org/isni/0000000359250963</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5032-4746</idno>
              <affiliation ref="#struct-437012"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Open Archive Toulouse Archive Ouverte</forename>
                <surname>(OATAO)</surname>
              </persName>
              <email type="md5">ac3f71840d50da799c1bb19c7b808bac</email>
              <email type="domain">listes-diff.inp-toulouse.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-05-29 10:49:32</date>
              <date type="whenModified">2025-10-22 18:04:08</date>
              <date type="whenReleased">2019-06-03 16:15:43</date>
              <date type="whenProduced">2018-03-15</date>
              <date type="whenEndEmbargoed">2019-05-29</date>
              <ref type="file" target="https://hal.science/hal-02143190v1/document">
                <date notBefore="2019-05-29"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-02143190v1/file/Choque_22956.pdf" id="file-2143190-2134366">
                <date notBefore="2019-05-29"/>
              </ref>
              <ref type="externalLink" target="https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-018-4574-4"/>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>Scientists</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="146910">
                <persName>
                  <forename>Open Archive Toulouse Archive Ouverte</forename>
                  <surname>(OATAO)</surname>
                </persName>
                <email type="md5">ac3f71840d50da799c1bb19c7b808bac</email>
                <email type="domain">listes-diff.inp-toulouse.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02143190</idno>
            <idno type="halUri">https://hal.science/hal-02143190</idno>
            <idno type="halBibtex">choque:hal-02143190</idno>
            <idno type="halRefHtml">&lt;i&gt;BMC Genomics&lt;/i&gt;, 2018, 19 (1), pp.0. &lt;a target="_blank" href="https://dx.doi.org/10.1186/s12864-018-4574-4"&gt;&amp;#x27E8;10.1186/s12864-018-4574-4&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">BMC Genomics, 2018, 19 (1), pp.0. &amp;#x27E8;10.1186/s12864-018-4574-4&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-2143190-2134366"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="GENETIQUE_ANIMALE">Département GA INRAE</idno>
            <idno type="stamp" n="LGC">Laboratoire de Génie Chimique</idno>
            <idno type="stamp" n="U-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="BIOPI-UPJV" corresp="U-PICARDIE">BioEcoAgro - UPJV</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="BIOECOAGRO-UPJV" corresp="U-PICARDIE">Transfrontalière BioEcoAgro-UPJV</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Whole-genome sequencing of Aspergillus tubingensis G131 and overview of its secondary metabolism potential</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Élodie</forename>
                    <surname>Choque</surname>
                  </persName>
                  <email type="md5">f12294d35673fa5c7961be0e628bda12</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="numeric">1151835</idno>
                  <idno type="halauthorid" notation="string">1497992-1151835</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5261-0738</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CLS-0773-2022</idno>
                  <idno type="IDREF">https://www.idref.fr/16652882X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CLS-0773-2022</idno>
                  <affiliation ref="#struct-509622"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Klopp</surname>
                  </persName>
                  <email type="md5">f93857cbb1e31166591501eb948338d3</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">0000-0001-7126-5477</idno>
                  <idno type="idhal" notation="numeric">735911</idno>
                  <idno type="halauthorid" notation="string">2518060-735911</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7126-5477</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-92114"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Valiere</surname>
                  </persName>
                  <email type="md5">ca3a84271452ef50e0d4455114077fb1</email>
                  <email type="domain">toulouse.inra.fr</email>
                  <idno type="idhal" notation="string">sophie-valiere</idno>
                  <idno type="idhal" notation="numeric">1203291</idno>
                  <idno type="halauthorid" notation="string">1237166-1203291</idno>
                  <idno type="ORCID">https://orcid.org/0009-0000-3430-7164</idno>
                  <affiliation ref="#struct-92114"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">José</forename>
                    <surname>Raynal</surname>
                  </persName>
                  <idno type="halauthorid">893754-0</idno>
                  <affiliation ref="#struct-437012"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Mathieu</surname>
                  </persName>
                  <email type="md5">7bc5b46b1f1552021a22c030ef910270</email>
                  <email type="domain">toulouse-inp.fr</email>
                  <idno type="idhal" notation="string">florence-mathieu</idno>
                  <idno type="idhal" notation="numeric">766766</idno>
                  <idno type="halauthorid" notation="string">655049-766766</idno>
                  <idno type="IDREF">https://www.idref.fr/12722887X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3071-9561</idno>
                  <idno type="VIAF">https://viaf.org/viaf/306435508</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000359250963</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5032-4746</idno>
                  <affiliation ref="#struct-437012"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">333</idno>
                <idno type="issn">1471-2164</idno>
                <title level="j">BMC Genomics</title>
                <imprint>
                  <publisher>BioMed Central</publisher>
                  <biblScope unit="volume">19</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">0</biblScope>
                  <date type="datePub">2018-03-15</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1186/s12864-018-4574-4</idno>
              <idno type="prodinra">444590</idno>
              <idno type="pubmed">29703136</idno>
              <idno type="wos">000444026500001</idno>
              <ref target="https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4574-4" type="seeAlso"/>
              <ref type="publisher">https://bmcgenomics.biomedcentral.com/</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Black aspergilli</term>
                <term xml:lang="en">Aspergillus tubingensis</term>
                <term xml:lang="en">Genomics</term>
                <term xml:lang="en">Secondary metabolism</term>
              </keywords>
              <classCode scheme="halDomain" n="chim.geni">Chemical Sciences/Chemical engineering</classCode>
              <classCode scheme="halDomain" n="spi.gproc">Engineering Sciences [physics]/Chemical and Process Engineering</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background : Black Aspergilli represent one of the most important fungal resources of primary and secondary metabolites for biotechnological industry. Having several black Aspergilli sequenced genomes should allow targeting the production of certain metabolites with bioactive properties. In this study, we report the draft genome of a black Aspergilli, A. tubingensis G131, isolated from a French Mediterranean vineyard. This 35 Mb genome includes 10,994 predicted genes. A genomic-based discovery identifies 80 secondary metabolites biosynthetic gene clusters. Genomic sequences of these clusters were blasted on 3 chosen black Aspergilli genomes: A. tubingensis CBS 134.48, A. niger CBS 513.88 and A. kawachii IFO 4308. This comparison highlights different levels of clusters conservation between the four strains. It also allows identifying seven unique clusters in A. tubingensis G131. Moreover, the putative secondary metabolites clusters for asperazine and naphtho-gamma-pyrones production were proposed based on this genomic analysis. Key biosynthetic genes required for the production of 2 mycotoxins, ochratoxin A and fumonisin, are absent from this draft genome. Even if intergenic sequences of these mycotoxins biosynthetic pathways are present, this could not lead to the production of those mycotoxins by A. tubingensis G131.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-509622" status="OLD">
          <idno type="IdRef">224228013</idno>
          <idno type="RNSR">200414213L</idno>
          <orgName>Biologie des Plantes et Innovation - UR UPJV 3900</orgName>
          <orgName type="acronym">BIOPI</orgName>
          <date type="start">2004-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Picardie Jules Verne - UFR des Sciences - 33, rue Saint Leu - 80039 AMIENS CEDEX 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biopi.u-picardie.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UR3900" active="#struct-300258" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-437012" status="OLD">
          <idno type="IdRef">085790605</idno>
          <idno type="ISNI">0000 0000 8797 4983</idno>
          <idno type="RNSR">199511947M</idno>
          <idno type="ROR">https://ror.org/003jnac13</idno>
          <orgName>Laboratoire de Génie Chimique</orgName>
          <orgName type="acronym">LGC</orgName>
          <date type="start">1992-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>4 allee Emile Monso 31432 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://lgc.cnrs.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR5503" active="#struct-441569" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300258" status="VALID">
          <idno type="IdRef">026403714</idno>
          <idno type="ISNI">0000 0001 0789 1385</idno>
          <idno type="ROR">https://ror.org/01gyxrk03</idno>
          <orgName>Université de Picardie Jules Verne</orgName>
          <orgName type="acronym">UPJV</orgName>
          <desc>
            <address>
              <addrLine>Chemin du Thil - 80000 Amiens</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.u-picardie.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>