Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue The Journal of Gene Medicine Année : 2000

Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells

Isabelle Fajac
  • Fonction : Auteur
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J.C Allo
  • Fonction : Auteur
Evelyne Souil
  • Fonction : Auteur
Marc Merten
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  • IdRef : 095237127
Chantal Pichon
Catherine Figarella
  • Fonction : Auteur
Pascale Briand
  • Fonction : Auteur
Patrick Midoux

Résumé

We recently designed a cationic polymer called histidylated polylysine made of polylysine partially substituted with histidyl residues which become protonated at slightly acidic pH. This polymer is thought to induce the leakage of acidic vesicles containing plasmid/histidylated polylysine complexes.

Dates et versions

hal-02135988 , version 1 (21-05-2019)

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Citer

Isabelle Fajac, J.C Allo, Evelyne Souil, Marc Merten, Chantal Pichon, et al.. Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells. The Journal of Gene Medicine, 2000, 2 (5), pp.368-378. ⟨10.1002/1521-2254(200009/10)2:5<368::AID-JGM118>3.0.CO;2-F⟩. ⟨hal-02135988⟩
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