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Article Dans Une Revue The Journal of Gene Medicine Année : 2002

Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates

Christine Gonçalves
Chantal Pichon
Patrick Midoux

Résumé

Glycosylated polylysines and histidylated polylysines complexed with plasmid DNA (pDNA) were proposed to develop polymer-based gene delivery systems. The present work has been undertaken in two steps to study the uptake and the intracellular processing of pDNA, which are still poorly understood in the polyfection pathway.

Dates et versions

hal-02135970 , version 1 (21-05-2019)

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Christine Gonçalves, Chantal Pichon, Brigitte Guérin, Patrick Midoux. Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates. The Journal of Gene Medicine, 2002, 4 (3), pp.271-281. ⟨10.1002/jgm.277⟩. ⟨hal-02135970⟩
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