<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02131883</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T00:55:55+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J -Resolved NMR Spectroscopy</title>
            <author role="aut">
              <persName>
                <forename type="first">Davy</forename>
                <surname>Sinnaeve</surname>
              </persName>
              <email type="md5">7b00aabd24bd36f4dc77aaa1001f002b</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">davysinnaeve</idno>
              <idno type="idhal" notation="numeric">179815</idno>
              <idno type="halauthorid" notation="string">12547-179815</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-2293-2013</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2556-5895</idno>
              <idno type="IDREF">https://www.idref.fr/253119510</idno>
              <affiliation ref="#struct-55421"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mickael</forename>
                <surname>Dinclaux</surname>
              </persName>
              <email type="md5">9e17411b888140580ba71a120f90c889</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">mickael-dinclaux</idno>
              <idno type="idhal" notation="numeric">175563</idno>
              <idno type="halauthorid" notation="string">36931-175563</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3860-7353</idno>
              <affiliation ref="#struct-135535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Edern</forename>
                <surname>Cahoreau</surname>
              </persName>
              <email type="md5">25639dc83b259552dcc1f54c7429c207</email>
              <email type="domain">insa-toulouse.fr</email>
              <idno type="idhal" notation="string">edern-cahoreau</idno>
              <idno type="idhal" notation="numeric">761327</idno>
              <idno type="halauthorid" notation="string">993094-761327</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8637-0448</idno>
              <affiliation ref="#struct-135535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Millard</surname>
              </persName>
              <email type="md5">bd63213bdf78c359e3d76bea15d87262</email>
              <email type="domain">insa-toulouse.fr</email>
              <idno type="idhal" notation="string">pierre-millard</idno>
              <idno type="idhal" notation="numeric">174338</idno>
              <idno type="halauthorid" notation="string">28821-174338</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8136-9963</idno>
              <idno type="IDREF">https://www.idref.fr/168620960</idno>
              <affiliation ref="#struct-135535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Charles</forename>
                <surname>Portais</surname>
              </persName>
              <email type="md5">8ee130aca7a8eb07f528f71680788f01</email>
              <email type="domain">insa-toulouse.fr</email>
              <idno type="idhal" notation="numeric">1097795</idno>
              <idno type="halauthorid" notation="string">875975-1097795</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3480-0933</idno>
              <idno type="IDREF">https://www.idref.fr/058637397</idno>
              <affiliation ref="#struct-135535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabien</forename>
                <surname>Letisse</surname>
              </persName>
              <email type="md5">19f2c108c10bc2b1d51016b230f10aea</email>
              <email type="domain">insa-toulouse.fr</email>
              <idno type="idhal" notation="string">fabien-letisse</idno>
              <idno type="idhal" notation="numeric">176275</idno>
              <idno type="halauthorid" notation="string">993292-176275</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1490-0152</idno>
              <idno type="IDREF">https://www.idref.fr/082845913</idno>
              <affiliation ref="#struct-135535"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Guy</forename>
                <surname>Lippens</surname>
              </persName>
              <email type="md5">8b81dee5610b542d0d181f88fac72bd6</email>
              <email type="domain">insa-toulouse.fr</email>
              <ptr type="url" target="https://www.toulouse-biotechnology-institute.fr/poles/equipe-rmn-2/"/>
              <idno type="idhal" notation="string">guy-lippens</idno>
              <idno type="idhal" notation="numeric">1152294</idno>
              <idno type="halauthorid" notation="string">133469-1152294</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8236-0901</idno>
              <idno type="IDREF">https://www.idref.fr/061529613</idno>
              <affiliation ref="#struct-135535"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pierre</forename>
                <surname>Millard</surname>
              </persName>
              <email type="md5">4087fbe9ec762d4b12e143063040a551</email>
              <email type="domain">insa-toulouse.fr</email>
            </editor>
            <funder ref="#projanr-50454"/>
            <funder>Research Foundation Flanders (FWO-Vlaanderen); Region Midi-Pyrenees; ERDF; SICOVAL; French Minister of Education Research</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-05-16 16:05:59</date>
              <date type="whenModified">2026-01-22 12:20:05</date>
              <date type="whenReleased">2019-05-16 16:05:59</date>
              <date type="whenProduced">2018-02-21</date>
              <ref type="externalLink" target="https://biblio.ugent.be/publication/8561209/file/8561210"/>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="364065">
                <persName>
                  <forename>Pierre</forename>
                  <surname>Millard</surname>
                </persName>
                <email type="md5">4087fbe9ec762d4b12e143063040a551</email>
                <email type="domain">insa-toulouse.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02131883</idno>
            <idno type="halUri">https://hal.science/hal-02131883</idno>
            <idno type="halBibtex">sinnaeve:hal-02131883</idno>
            <idno type="halRefHtml">&lt;i&gt;Analytical Chemistry&lt;/i&gt;, 2018, 90 (6), pp.4025-4031. &lt;a target="_blank" href="https://dx.doi.org/10.1021/acs.analchem.7b05206"&gt;&amp;#x27E8;10.1021/acs.analchem.7b05206&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Analytical Chemistry, 2018, 90 (6), pp.4025-4031. &amp;#x27E8;10.1021/acs.analchem.7b05206&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INSA-TOULOUSE">Institut National des Sciences Appliquées de Toulouse</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="TBI" corresp="INSA-TOULOUSE">Toulouse Biotechnology Institute</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="INRAEOCCITANIETOULOUSE" corresp="INRAE">INRAE Occitanie Toulouse</idno>
            <idno type="stamp" n="TBI-PRISM" corresp="TBI">Pôle PRISM du laboratoire TBI</idno>
            <idno type="stamp" n="TBI-TECH" corresp="TBI">Pôle Technologique</idno>
            <idno type="stamp" n="METABOHUB">Metabohub : Infrastructure nationale en métabolomique et fluxomique </idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J -Resolved NMR Spectroscopy</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Davy</forename>
                    <surname>Sinnaeve</surname>
                  </persName>
                  <email type="md5">7b00aabd24bd36f4dc77aaa1001f002b</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">davysinnaeve</idno>
                  <idno type="idhal" notation="numeric">179815</idno>
                  <idno type="halauthorid" notation="string">12547-179815</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-2293-2013</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2556-5895</idno>
                  <idno type="IDREF">https://www.idref.fr/253119510</idno>
                  <affiliation ref="#struct-55421"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mickael</forename>
                    <surname>Dinclaux</surname>
                  </persName>
                  <email type="md5">9e17411b888140580ba71a120f90c889</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">mickael-dinclaux</idno>
                  <idno type="idhal" notation="numeric">175563</idno>
                  <idno type="halauthorid" notation="string">36931-175563</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3860-7353</idno>
                  <affiliation ref="#struct-135535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Edern</forename>
                    <surname>Cahoreau</surname>
                  </persName>
                  <email type="md5">25639dc83b259552dcc1f54c7429c207</email>
                  <email type="domain">insa-toulouse.fr</email>
                  <idno type="idhal" notation="string">edern-cahoreau</idno>
                  <idno type="idhal" notation="numeric">761327</idno>
                  <idno type="halauthorid" notation="string">993094-761327</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8637-0448</idno>
                  <affiliation ref="#struct-135535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Millard</surname>
                  </persName>
                  <email type="md5">bd63213bdf78c359e3d76bea15d87262</email>
                  <email type="domain">insa-toulouse.fr</email>
                  <idno type="idhal" notation="string">pierre-millard</idno>
                  <idno type="idhal" notation="numeric">174338</idno>
                  <idno type="halauthorid" notation="string">28821-174338</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8136-9963</idno>
                  <idno type="IDREF">https://www.idref.fr/168620960</idno>
                  <affiliation ref="#struct-135535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Charles</forename>
                    <surname>Portais</surname>
                  </persName>
                  <email type="md5">8ee130aca7a8eb07f528f71680788f01</email>
                  <email type="domain">insa-toulouse.fr</email>
                  <idno type="idhal" notation="numeric">1097795</idno>
                  <idno type="halauthorid" notation="string">875975-1097795</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3480-0933</idno>
                  <idno type="IDREF">https://www.idref.fr/058637397</idno>
                  <affiliation ref="#struct-135535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabien</forename>
                    <surname>Letisse</surname>
                  </persName>
                  <email type="md5">19f2c108c10bc2b1d51016b230f10aea</email>
                  <email type="domain">insa-toulouse.fr</email>
                  <idno type="idhal" notation="string">fabien-letisse</idno>
                  <idno type="idhal" notation="numeric">176275</idno>
                  <idno type="halauthorid" notation="string">993292-176275</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1490-0152</idno>
                  <idno type="IDREF">https://www.idref.fr/082845913</idno>
                  <affiliation ref="#struct-135535"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Guy</forename>
                    <surname>Lippens</surname>
                  </persName>
                  <email type="md5">8b81dee5610b542d0d181f88fac72bd6</email>
                  <email type="domain">insa-toulouse.fr</email>
                  <ptr type="url" target="https://www.toulouse-biotechnology-institute.fr/poles/equipe-rmn-2/"/>
                  <idno type="idhal" notation="string">guy-lippens</idno>
                  <idno type="idhal" notation="numeric">1152294</idno>
                  <idno type="halauthorid" notation="string">133469-1152294</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8236-0901</idno>
                  <idno type="IDREF">https://www.idref.fr/061529613</idno>
                  <affiliation ref="#struct-135535"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">2974</idno>
                <idno type="issn">0003-2700</idno>
                <idno type="eissn">1520-6882</idno>
                <title level="j">Analytical Chemistry</title>
                <imprint>
                  <publisher>American Chemical Society</publisher>
                  <biblScope unit="volume">90</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">4025-4031</biblScope>
                  <date type="datePub">2018-02-21</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1021/acs.analchem.7b05206</idno>
              <idno type="prodinra">452214</idno>
              <idno type="pubmed">29481062</idno>
              <idno type="wos">000428219600054</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.bibs">Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]</classCode>
              <classCode scheme="halDomain" n="sdv.bio">Life Sciences [q-bio]/Biotechnology</classCode>
              <classCode scheme="vocinrae-old" n="spectroscopie rmn">spectroscopie rmn</classCode>
              <classCode scheme="vocinrae-old" n="carbone">carbone</classCode>
              <classCode scheme="vocinrae-old" n="isotope">isotope</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Quantitative information on the carbon isotope content of metabolites is essential for flux analysis. Whereas this information is in principle present in proton NMR spectra through both direct and long-range heteronuclear coupling constants, spectral overlap and homonuclear coupling constants both hinder its extraction. We demonstrate here how pure shift 2D J-resolved NMR spectroscopy can simultaneously remove the homonuclear couplings and separate the chemical shift information from the heteronuclear coupling patterns. We demonstrate the power of this method on cell lysates from different bacterial cultures and investigate in detail the branched chain amino acid biosynthesis.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-55421" status="INCOMING">
          <orgName>Department of organic Chemistry</orgName>
          <desc>
            <address>
              <addrLine>Faculty of Science Krijgslaan 281 S4 9000 GHENT</addrLine>
              <country key="BE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-302729" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-135535" status="OLD">
          <idno type="IdRef">155508717</idno>
          <orgName>Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés</orgName>
          <orgName type="acronym">LISBP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-07-05</date>
          <desc>
            <address>
              <addrLine>135 Avenue de rangueil 31077 Toulouse cedex 04</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lisbp.fr/fr/index.html</ref>
          </desc>
          <listRelation>
            <relation name="UMR0792" active="#struct-92114" type="direct"/>
            <relation active="#struct-116255" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR5504" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-302729" status="VALID">
          <idno type="ROR">https://ror.org/00cv9y106</idno>
          <orgName>Universiteit Gent = Ghent University = Université de Gand</orgName>
          <orgName type="acronym">UGent</orgName>
          <date type="start">1817-01-01</date>
          <desc>
            <address>
              <addrLine>St. Pietersnieuwstraat 33, 9000 Gent</addrLine>
              <country key="BE"/>
            </address>
            <ref type="url">https://www.ugent.be/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-116255" status="VALID">
          <idno type="IdRef">026388766</idno>
          <idno type="ISNI">0000 0001 2286 8343</idno>
          <idno type="ROR">https://ror.org/01h8pf755</idno>
          <idno type="Wikidata">Q858979</idno>
          <orgName>Institut National des Sciences Appliquées - Toulouse</orgName>
          <orgName type="acronym">INSA Toulouse</orgName>
          <date type="start">1963-10-21</date>
          <desc>
            <address>
              <addrLine>135, avenue de Rangueil - 31077 Toulouse cedex 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-toulouse.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301232" type="direct"/>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50454" status="VALID">
          <idno type="anr">ANR-11-INBS-0010</idno>
          <orgName>METABOHUB</orgName>
          <desc>Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>