Article Dans Une Revue Chemistry - A European Journal Année : 2011

A Diverted Total Synthesis of Mycolactone Analogues: An Insight into Buruli Ulcer Toxins

Laure Guenin-Macé
Caroline Demangel

Résumé

Mycolactones are complex macrolides responsible for a severe necrotizing skin disease called Buruli ulcer. Deciphering their functional interactions is of fundamental importance for the understanding, and ultimately, the control of this devastating mycobacterial infection. We report herein a diverted total synthesis approach of mycolactones analogues and provide the first insights into their structure–activity relationship based on cytopathic assays on L929 fibroblasts. The lowest concentration inducing a cytopathic effect was determined for selected analogues, allowing a clear picture to emerge by comparison with the natural toxins.

Dates et versions

hal-02128753 , version 1 (14-05-2019)

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Citer

Anne-Caroline Chany, Virginie Casarotto, Marjorie Schmitt, Céline Tarnus, Laure Guenin-Macé, et al.. A Diverted Total Synthesis of Mycolactone Analogues: An Insight into Buruli Ulcer Toxins. Chemistry - A European Journal, 2011, 17 (51), pp.14413-14419. ⟨10.1002/chem.201102542⟩. ⟨hal-02128753⟩
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