Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme
Résumé
Therapeutic intravenous immunoglobulin preparations (IVIg) are used for treatment of wide range of auto-immune and inflammatory diseases. Versatile mechanisms have been reported to contribute to the im-munomodulatory effects of IVIg. Here we demonstrate that IVIg has a strong potential to inhibit pro-in-flammatory effect of extracellular heme. Indeed, the presence of immunoglobulins reduced the potential of heme to activate the complement system on the surface of human endothelial cells. Since extracellular heme is considered as one of the principal pathogenic factors in hemolytic disorders, its therapeutic scavenging by IVIg may have significant clinical repercussions.
Origine | Publication financée par une institution |
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