Distributed medical information systems are prone to security flaws at three main different levels: storage, processing and transmission. Among implemented security mechanisms, few con cern intrinsic patien t records multimedia content protection. This art icle presents a S ecured Specialized Electronic Patient Record (SSEPR) based on a JPEG2000- XML structure designed to pr ovide interaction with the Medical Information System (MIS ) security mech anisms and policies. Such SSEPR is an Elect ronic Patient Record (EPR) elementary resource, containing data and information generated by daily practice in a technical medical unit, grouping information that belongs to one patient examination (images, examination data, medical report). Devoted to be handled and shared, it integr ates different security attributes that are used to certify infor mation reliability (information integrity and authenticity), while controlling information access in a compliant MIS. Aiming to be as generic as possible, the presented SSEPR and its platform prototype have been developed in the framework of a nuclear medicine service. Properly defined, EPR security layer can be used to improve security in handling and sharing medical information.