<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02122570</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T01:00:29+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Determination of rimantadine in pharmaceutical preparations by capillary zone electrophoresis with indirect detection or after derivatization</title>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Revilla</surname>
              </persName>
              <idno type="halauthorid">1580537-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Hamacek</surname>
              </persName>
              <email type="md5">3fb4c6ef46d7e1d807879002a4902f41</email>
              <email type="domain">cnrs.fr</email>
              <idno type="idhal" notation="string">josef-hamacek</idno>
              <idno type="idhal" notation="numeric">174907</idno>
              <idno type="halauthorid" notation="string">1126170-174907</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4641-7357</idno>
              <idno type="IDREF">https://www.idref.fr/19155006X</idno>
              <affiliation ref="#struct-480895"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Lubal</surname>
              </persName>
              <idno type="halauthorid">655452-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Havel</surname>
              </persName>
              <idno type="halauthorid">1534291-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laëtitia</forename>
                <surname>LEGOUPIL</surname>
              </persName>
              <email type="md5">e9a3fa0bdfd22a9d0a2d2ac46e7772a2</email>
              <email type="domain">cnrs-orleans.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-05-07 14:17:37</date>
              <date type="whenModified">2025-04-16 09:38:30</date>
              <date type="whenReleased">2019-05-07 14:17:37</date>
              <date type="whenProduced">1998-04</date>
              <ref type="externalLink" target="https://api.istex.fr/document/29B71D398CEE40FE348D086BC39861A5A9CA5481/fulltext/pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="712555">
                <persName>
                  <forename>Laëtitia</forename>
                  <surname>LEGOUPIL</surname>
                </persName>
                <email type="md5">e9a3fa0bdfd22a9d0a2d2ac46e7772a2</email>
                <email type="domain">cnrs-orleans.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02122570</idno>
            <idno type="halUri">https://hal.science/hal-02122570</idno>
            <idno type="halBibtex">revilla:hal-02122570</idno>
            <idno type="halRefHtml">&lt;i&gt;Chromatographia&lt;/i&gt;, 1998, 47 (7-8), pp.433-439. &lt;a target="_blank" href="https://dx.doi.org/10.1007/BF02466475"&gt;&amp;#x27E8;10.1007/BF02466475&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Chromatographia, 1998, 47 (7-8), pp.433-439. &amp;#x27E8;10.1007/BF02466475&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt/>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Determination of rimantadine in pharmaceutical preparations by capillary zone electrophoresis with indirect detection or after derivatization</title>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Revilla</surname>
                  </persName>
                  <idno type="halauthorid">1580537-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Hamacek</surname>
                  </persName>
                  <email type="md5">3fb4c6ef46d7e1d807879002a4902f41</email>
                  <email type="domain">cnrs.fr</email>
                  <idno type="idhal" notation="string">josef-hamacek</idno>
                  <idno type="idhal" notation="numeric">174907</idno>
                  <idno type="halauthorid" notation="string">1126170-174907</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4641-7357</idno>
                  <idno type="IDREF">https://www.idref.fr/19155006X</idno>
                  <affiliation ref="#struct-480895"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Lubal</surname>
                  </persName>
                  <idno type="halauthorid">655452-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Havel</surname>
                  </persName>
                  <idno type="halauthorid">1534291-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11707</idno>
                <idno type="issn">0009-5893</idno>
                <idno type="eissn">1612-1112</idno>
                <title level="j">Chromatographia</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">47</biblScope>
                  <biblScope unit="issue">7-8</biblScope>
                  <biblScope unit="pp">433-439</biblScope>
                  <date type="datePub">1998-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/BF02466475</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Dissolution testing</term>
                <term xml:lang="en">Indirect detection</term>
                <term xml:lang="en">Rimantadine</term>
                <term xml:lang="en">Capillary zone electrophoresis</term>
              </keywords>
              <classCode scheme="halDomain" n="chim">Chemical Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Rimantadine is synthetic analog of amantadine; both are antiviral agents used for prophylaxis and treatment of influenza A. A capillary zone electrophoretic (CZE) procedure for the determination of rimantadine has been developed. As the direct determination of rimantadine is poorly sensitive because the compound is almost transparent in the UV/Vis range, several indirect methods were studied. Two were found to be the particularly useful: (a) indirect detection using 5 mM 4-methylbenzylamine in 1:4 methanol-water as absorbing background electrolyte, with detection at 210 nm, and (b) derivatization of rimantadine with 1,2-naphthoquinone-4-sulfonic acid in alkaline medium and subsequent determination of the derivative by CZE (40 mM tetraborate, pH 9.2, detection at 280 nm). Uncoated capillary tubing, 44 cm length ×75 μM i.d., was used for both determinations. The detection limits were 0.1 and 2 ppm for methods a and b, respectively. The methods were used to determine rimantadine in pharmaceutical products and for dissolution testing of Flumadin® tablets.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-480895" status="VALID">
          <orgName>Faculty of Science [Brno]</orgName>
          <orgName type="acronym">SCI / MUNI</orgName>
          <desc>
            <address>
              <addrLine>Masaryk University Kotlářská 267/2, 611 37 Brno</addrLine>
              <country key="CZ"/>
            </address>
            <ref type="url">https://www.sci.muni.cz/en</ref>
          </desc>
          <listRelation>
            <relation active="#struct-412450" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-412450" status="VALID">
          <idno type="IdRef">030138566</idno>
          <idno type="ISNI">0000000121940956</idno>
          <idno type="ROR">https://ror.org/02j46qs45</idno>
          <idno type="Wikidata">Q763586</idno>
          <orgName>Masaryk University [Brno] = Masarykova univerzita [Brno] = Université Masaryk [Brno]</orgName>
          <orgName type="acronym">MU / MUNI</orgName>
          <date type="start">1919-01-28</date>
          <desc>
            <address>
              <addrLine>Žerotínovo nám. 617/9 – 601 77 Brno – Czech Republic</addrLine>
              <country key="CZ"/>
            </address>
            <ref type="url">https://www.muni.cz/en</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>