Maghemite Nanoparticles with Enhanced Magnetic Properties: One-Pot Preparation and Ultrastable Dextran Shell - Archive ouverte HAL Access content directly
Journal Articles ACS Applied Materials & Interfaces Year : 2018

Maghemite Nanoparticles with Enhanced Magnetic Properties: One-Pot Preparation and Ultrastable Dextran Shell

Abstract

In the field of nanomedicine, superparamagnetic nanoparticles are one of the most studied nanomaterials for theranostics. In this study, a one-pot synthesis of magnetic nanoparticles is presented, with an increased control on particle size from 10 to 40 nm. Monitoring of vacuum level is introduced here as a crucial parameter for achieving a fine particle morphology. The magnetic properties of these nanoparticles are highly affected by disorders or mismatches in crystal structure. A prolonged oxidation step is applied to the obtained nanoparticles to transform the magnetic phases into a pure maghemite one, confirmed by high-resolution X-ray photoelectron spectroscopy analysis, by Mössbauer spectrometry and, indirectly, by increased performances in magnetization curves and in relaxation times. Afterward, the attained nanoparticles are transferred into water by a nonderivatized dextran coating. Thermogravimetric analysis confirms that polysaccharide molecules replace oleic acid on the surface by stabilizing the particles in the aqueous phase and culture media. Preliminary in vitro test reveals that the dextran-coated nanoparticles are not passively internalized from the cells. As a proof of concept, a secondary layer of chitosan assures a positive charge to the nanoparticle surface, thus enhancing cellular internalization.
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hal-02120571 , version 1 (06-05-2019)

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Riccardo Di Corato, Alessandra Aloisi, Simona Rella, Jean-Marc Greneche, Giammarino Pugliese, et al.. Maghemite Nanoparticles with Enhanced Magnetic Properties: One-Pot Preparation and Ultrastable Dextran Shell. ACS Applied Materials & Interfaces, 2018, 10 (24), pp.20271-20280. ⟨10.1021/acsami.7b18411⟩. ⟨hal-02120571⟩
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