Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 1990

Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system.

K Rieger
  • Fonction : Auteur
D Schott
  • Fonction : Auteur
M Morgat
  • Fonction : Auteur
E Hannappel
  • Fonction : Auteur
W Voelter
  • Fonction : Auteur
M Lenfant
  • Fonction : Auteur

Résumé

It is shown that AcSDKP a new regulator of the hematopoietic system can be generated from thymosin beta 4 by a one-step enzymatic cleavage in vitro and in vivo. AcSDKP and T beta 4 were both detected in bone marrow cells (BMC). Incubation of [3H]T beta 4 with either intact or lysed BMC led to the formation of [3H]AcSDKP whereas the labelled tetrapeptide was not degraded under these conditions. Model enzymatic degradation of T beta 4 carried out with bacterial enzymes suggests that a mammalian endoproteinase Asp-N might be involved in the formation of AcSDKP through the specific cleavage of the 4Pro-5 Asp peptide bond of T beta 4.
Fichier non déposé

Dates et versions

hal-02114986 , version 1 (30-04-2019)

Identifiants

  • HAL Id : hal-02114986 , version 1
  • PUBMED : 2253778

Citer

Catherine Grillon, K Rieger, J. Bakala, D Schott, M Morgat, et al.. Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system.. FEBS Letters, 1990, 274 (1-2), pp.30-4. ⟨hal-02114986⟩
19 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More