HCoV-229E spike protein fusion activation by trypsin-like serine proteases is mediated by proteolytic processing in the S2′ region - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of General Virology Année : 2018

HCoV-229E spike protein fusion activation by trypsin-like serine proteases is mediated by proteolytic processing in the S2′ region

Résumé

Human coronavirus 229E (HCoV-229E) is responsible for common colds. Like other coronaviruses, HCoV-229E exploits cellular proteases to activate fusion mediated by the spike protein. We analysed the proteolytic processing of the HCoV-229E spike protein by trypsin-like serine proteases leading to activation of the fusion process. Unlike in other coronaviruses, HCoV-229E fusion activation appears to be a one-step process. Indeed, cleavage of the S1/S2 interface does not seem to be a prerequisite, and the fusion activation is highly reliant on the S2′ region, with arginine residue 683 acting as the recognition site.

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Virologie
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Dates et versions

hal-02112472 , version 1 (26-04-2019)

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Ariane Bonnin, Adeline Danneels, Jean Dubuisson, Anne Goffard, Sandrine Belouzard. HCoV-229E spike protein fusion activation by trypsin-like serine proteases is mediated by proteolytic processing in the S2′ region. Journal of General Virology, 2018, 99 (7), pp.908-912. ⟨10.1099/jgv.0.001074⟩. ⟨hal-02112472⟩
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