New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.G mel .) C.A. Sm . - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemistry and Biodiversity Année : 2017

New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.G mel .) C.A. Sm .

Résumé

As part of our search for new bioactive saponins from Cameroonian medicinal plants, two new oleanane‐type saponins, named gummiferaosides D and E (1 and 2), along with one known saponin, julibroside J8 (3), were isolated from the roots of Albizia gummifera. Their structures were established on the basis of extensive 1D‐ and 2D‐NMR (1H‐ and 13C‐NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC‐TOCSY, and HMBC) and HR‐ESI‐MS studies, and by chemical evidence. The apoptotic effect of saponins 1 – 3 was evaluated on the A431 human epidermoid cancer cell. Flow cytometric analyses showed that saponins 1 – 3 induced apoptosis of human epidermoid cancer cell (A431) in a dose‐dependent manner.
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Dates et versions

hal-02106897 , version 1 (23-04-2019)

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Line Made Simo, Olivier Placide Noté, Joséphine Ngo Mbing, Sarah Ali Aouazou, Dominique Guillaume, et al.. New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.G mel .) C.A. Sm .. Chemistry and Biodiversity, 2017, 14 (10), pp.e1700260. ⟨10.1002/cbdv.201700260⟩. ⟨hal-02106897⟩
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