TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2018

TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction

Résumé

Graphical Abstract Highlights d C-LTMR neurons contact GABAergic neurons d TAFA4, a chemokine secreted by C-LMTR, promotes microglial process retraction d TAFA4 enables restoration of inhibitory inputs to spinal neurons d TAFA4 attenuates nociceptive transmission in the spinal cord In Brief TAFA4 is a recently discovered chemokine secreted by C-low-threshold mechanoreceptors (C-LTMRs). Kambrun et al. describe the interplay between C-LTMRs, spinal GABAergic neurons, and microglial cells that is responsible for the mechanical pain alleviation induced by TAFA4 by inflammation.
Fichier principal
Vignette du fichier
TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction..pdf (3.05 Mo) Télécharger le fichier
Origine Publication financée par une institution
Loading...

Dates et versions

hal-02106723 , version 1 (23-04-2019)

Licence

Identifiants

Citer

Charline Kambrun, Olivier Roca-Lapirot, Chiara Salio, Marc Landry, Aziz Moqrich, et al.. TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction. Cell Reports, 2018, 22 (11), pp.2886-2897. ⟨10.1016/j.celrep.2018.02.068⟩. ⟨hal-02106723⟩
73 Consultations
54 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More