TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction
Résumé
Graphical Abstract Highlights d C-LTMR neurons contact GABAergic neurons d TAFA4, a chemokine secreted by C-LMTR, promotes microglial process retraction d TAFA4 enables restoration of inhibitory inputs to spinal neurons d TAFA4 attenuates nociceptive transmission in the spinal cord In Brief TAFA4 is a recently discovered chemokine secreted by C-low-threshold mechanoreceptors (C-LTMRs). Kambrun et al. describe the interplay between C-LTMRs, spinal GABAergic neurons, and microglial cells that is responsible for the mechanical pain alleviation induced by TAFA4 by inflammation.
Domaines
Sciences du Vivant [q-bio]
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TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction..pdf (3.05 Mo)
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| Origine | Publication financée par une institution |
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