2,4-Bis(fluoroalkyl)quinoline-3-carboxylates as Tools for the Development of Potential Agrochemical Ingredients
Résumé
From an easy and scalable synthetic access to quinoline derivatives substituted by fluorinated groups in both C2-and C4-positions developed in our laboratory, we devised the synthesis of a new series of unprecedented 2,4-bis(fluoroalkyl)quinoline-3-carboxylates in two steps only. After standard saponification, the latter afforded their corresponding 2,4-bis(fluoroalkyl)quinoline-3-carboxylic acids, which served as pivotal intermediates for post-functionalization reactions. Indeed, the carboxylic function could then be derived according to known procedures and allowed the introduction of chemical diversity in C3-position of these unprecedented structures. The resulting highly functionalized quinolines will then serve as platform in the development of ingredients with strong potential for agrochemical research.
Domaines
Chimie organique
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