2,4-Bis(fluoroalkyl)quinoline-3-carboxylates as Tools for the Development of Potential Agrochemical Ingredients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2018

2,4-Bis(fluoroalkyl)quinoline-3-carboxylates as Tools for the Development of Potential Agrochemical Ingredients

Résumé

From an easy and scalable synthetic access to quinoline derivatives substituted by fluorinated groups in both C2-and C4-positions developed in our laboratory, we devised the synthesis of a new series of unprecedented 2,4-bis(fluoroalkyl)quinoline-3-carboxylates in two steps only. After standard saponification, the latter afforded their corresponding 2,4-bis(fluoroalkyl)quinoline-3-carboxylic acids, which served as pivotal intermediates for post-functionalization reactions. Indeed, the carboxylic function could then be derived according to known procedures and allowed the introduction of chemical diversity in C3-position of these unprecedented structures. The resulting highly functionalized quinolines will then serve as platform in the development of ingredients with strong potential for agrochemical research.

Domaines

Chimie organique
Fichier principal
Vignette du fichier
FA-EJOC-HAL.pdf (666.87 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02105501 , version 1 (13-11-2020)

Identifiants

Citer

Fallia Aribi, Armen Panossian, Jean-Pierre Vors, Sergiy Pazenok, Frédéric R. Leroux. 2,4-Bis(fluoroalkyl)quinoline-3-carboxylates as Tools for the Development of Potential Agrochemical Ingredients. European Journal of Organic Chemistry, 2018, Organofluorine Chemistry in Europe, 2018 (27-28), pp.3792-3802. ⟨10.1002/ejoc.201800375⟩. ⟨hal-02105501⟩
28 Consultations
74 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More