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Article Dans Une Revue Neural plasticity Année : 2017

Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors

Résumé

Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia. Recent data show that postsynaptic P2X receptors underlie slow neuromodulatory actions rather than fast synaptic transmission at brain synapses. Here, we review these findings with a particular focus on the release of ATP by astrocytes and the diversity of postsynaptic P2X-mediated modulation of synaptic strength and plasticity in the CNS.

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Neurobiologie
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hal-02104581 , version 1 (19-04-2019)

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Eric Boué-Grabot, Yuriy Pankratov. Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors. Neural plasticity, 2017, 2017, pp.1-11. ⟨10.1155/2017/9454275⟩. ⟨hal-02104581⟩

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