Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2017

Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

Résumé

Amyotrophic lateral sclerosis (ALS), the commonest adult-onset motor neuron disorder, is characterized by a survival span of only 2-5 years after onset. Relevant biomarkers or specific metabolic signatures would provide powerful tools for the management of ALS. The main objective of this study was to investigate the cerebrospinal fluid (CSF) lipidomic signature of ALS patients by mass spectrometry to evaluate the diagnostic and predictive values of the profile. We showed that ALS patients (n = 40) displayed a highly significant specific CSF lipidomic signature compared to controls (n = 45). Phosphatidylcholine PC(36:4), higher in ALS patients (p = 0.0003) was the most discriminant molecule, and ceramides and glucosylceramides were also highly relevant. Analysis of targeted lipids in the brain cortex of ALS model mice confirmed the role of some discriminant lipids such as PC. We also obtained good models for predicting the variation of the ALSFRS-r score from the lipidome baseline, with an accuracy of 71% in an independent set of patients. Significant predictions of clinical evolution were found to be correlated to sphingomyelins and triglycerides with long-chain fatty acids. Our study, which shows extensive lipid remodelling in the CSF of ALS patients, provides a new metabolic signature of the disease and its evolution with good predictive performance.
Fichier principal
Vignette du fichier
41598_2017_Article_17389.pdf (1.52 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-02104331 , version 1 (11-04-2024)

Identifiants

Citer

Hélène Blasco, Charlotte Veyrat-Durebex, Cinzia Bocca, Franck Patin, Patrick Vourc'H, et al.. Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS. Scientific Reports, 2017, 7, pp.17652. ⟨10.1038/s41598-017-17389-9⟩. ⟨hal-02104331⟩
24 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More