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Article Dans Une Revue Chemical Communications Année : 2019

Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination

Anne Volbeda
Jean-Marc Latour
  • Fonction : Auteur
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Martin Clémancey
Debora Reichmann
  • Fonction : Auteur
Patricia Amara
Juan-Carlos Fontecilla-Camps

Résumé

Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.

Domaines

Catalyse
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Dates et versions

hal-02091389 , version 1 (05-04-2019)

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Citer

Jaione Saez Cabodevilla, Anne Volbeda, Olivier Hamelin, Jean-Marc Latour, Océane Gigarel, et al.. Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination. Chemical Communications, 2019, 55 (26), pp.3725-3728. ⟨10.1039/c8cc09023h⟩. ⟨hal-02091389⟩
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