Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination - Archive ouverte HAL Access content directly
Journal Articles Chemical Communications Year : 2019

Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination

Anne Volbeda
Jean-Marc Latour
  • Function : Author
  • PersonId : 859433
Martin Clémancey
Debora Reichmann
  • Function : Author
Patricia Amara
Juan-Carlos Fontecilla-Camps

Abstract

Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.
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hal-02091389 , version 1 (05-04-2019)

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Jaione Saez Cabodevilla, Anne Volbeda, Olivier Hamelin, Jean-Marc Latour, Océane Gigarel, et al.. Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination. Chemical Communications, 2019, 55 (26), pp.3725-3728. ⟨10.1039/c8cc09023h⟩. ⟨hal-02091389⟩
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