The ITGAV Rs3738919-C Allele Is Associated with Rheumatoid Arthritis in the European Caucasian Population: A Family-Based Study
Laurent Jacq
(1)
,
Sophie Garnier
(1)
,
Philippe Dieudé
(1)
,
Laëtitia Michou
(1)
,
Céline Pierlot
(2)
,
Paola Migliorini
,
Alejandro Balsa
,
René Westhovens
,
Pilar Barrera
,
Helena Alves
,
Carlos Vaz
,
Manuela Fernandes
(3)
,
Dora Pascual-Salcedo
,
Stefano Bombardieri
,
Jan Dequeker
,
Timothy R. Radstake
,
Piet van Riel
,
Leo van de Putte
,
Antonio Lopes-Vaz
,
Elodie Glikmans
,
Sandra Barbet
(1)
,
Sandra Lasbleiz
,
Isabelle Lemaire
(1)
,
Patrick Quillet
(1)
,
Pascal Hilliquin
(4, 1)
,
Vitor Hugo Teixeira
(1)
,
Elisabeth Petit-Teixeira
(1)
,
Hamdi Mbarek
(1)
,
Bernard Prum
(5)
,
Thomas Bardin
(6, 1)
,
François Cornélis
(1)
1
GenHotel -
Laboratoire de recherche européen pour la polyarthrite rhumatoïde
2 UMR CNRS 8009 - Laboratoire de Chimie Organique et Macromoleculaire
3 CICECO - Center for Research in Ceramic and Composite Materials
4 Centre Hospitalier Sud Francilien
5 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
6 Service de Rhumatologie [CHU Lariboisière]
2 UMR CNRS 8009 - Laboratoire de Chimie Organique et Macromoleculaire
3 CICECO - Center for Research in Ceramic and Composite Materials
4 Centre Hospitalier Sud Francilien
5 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
6 Service de Rhumatologie [CHU Lariboisière]
Sophie Garnier
- Fonction : Auteur
- PersonId : 934284
- IdHAL : sophie-garnier
- ORCID : 0000-0002-7492-1617
- IdRef : 113929218
Paola Migliorini
- Fonction : Auteur
Alejandro Balsa
- Fonction : Auteur
René Westhovens
- Fonction : Auteur
- PersonId : 791336
- ORCID : 0000-0002-3432-3073
Pilar Barrera
- Fonction : Auteur
Helena Alves
- Fonction : Auteur
Carlos Vaz
- Fonction : Auteur
Dora Pascual-Salcedo
- Fonction : Auteur
Stefano Bombardieri
- Fonction : Auteur
Jan Dequeker
- Fonction : Auteur
Timothy R. Radstake
- Fonction : Auteur
Piet van Riel
- Fonction : Auteur
Leo van de Putte
- Fonction : Auteur
Antonio Lopes-Vaz
- Fonction : Auteur
Elodie Glikmans
- Fonction : Auteur
Sandra Lasbleiz
- Fonction : Auteur
Elisabeth Petit-Teixeira
- Fonction : Auteur
- PersonId : 172206
- IdHAL : elisabeth-teixeira
- ORCID : 0000-0001-9724-3575
- IdRef : 147506638
Thomas Bardin
- Fonction : Auteur
- PersonId : 756614
- ORCID : 0000-0002-5080-4790
Résumé
The integrin αvβ3, whose αv subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility loci. Our aim was to test the ITGAV gene for association and linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide polymorphisms were genotyped by PCR-restriction fragment length polymorphism in 100 French Caucasian RA trio families (one RA patient and both parents), 100 other French families and 265 European families available for replication. The genetic analyses for association and linkage were performed using the comparison of allelic frequencies (affected family-based controls), the transmission disequilibrium test, and the genotype relative risk. We observed a significant RA association for the C allele of rs3738919 in the first sample (affected family-based controls, RA index cases 66.5% versus controls 56.7%; P = 0.04). The second sample showed the same trend, and the third sample again showed a significant RA association. When all sets were combined, the association was confirmed (affected family-based controls, RA index cases 64.6% versus controls 58.1%; P = 0.005). The rs3738919-C allele was also linked to RA (transmission disequilibrium test, 56.5% versus50% of transmission; P = 0.009) and the C-allele-containing genotype was more frequent in RA index cases than in controls (RA index cases 372 versus controls 339; P = 0.002, odds ratio = 1.94, 95% confidence interval = 1.3-2.9). The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene. © 2007 Jacq et al.; licensee BioMed Central Ltd.
Domaines
Génétique humaineFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
The ITGAV Rs3738919-C Allele Is Associated with Rheumatoid Arthritis in the European Caucasian Population: A Family-Based Study
|
Résumé |
en
The integrin αvβ3, whose αv subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility loci. Our aim was to test the ITGAV gene for association and linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide polymorphisms were genotyped by PCR-restriction fragment length polymorphism in 100 French Caucasian RA trio families (one RA patient and both parents), 100 other French families and 265 European families available for replication. The genetic analyses for association and linkage were performed using the comparison of allelic frequencies (affected family-based controls), the transmission disequilibrium test, and the genotype relative risk. We observed a significant RA association for the C allele of rs3738919 in the first sample (affected family-based controls, RA index cases 66.5% versus controls 56.7%; P = 0.04). The second sample showed the same trend, and the third sample again showed a significant RA association. When all sets were combined, the association was confirmed (affected family-based controls, RA index cases 64.6% versus controls 58.1%; P = 0.005). The rs3738919-C allele was also linked to RA (transmission disequilibrium test, 56.5% versus50% of transmission; P = 0.009) and the C-allele-containing genotype was more frequent in RA index cases than in controls (RA index cases 372 versus controls 339; P = 0.002, odds ratio = 1.94, 95% confidence interval = 1.3-2.9). The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene. © 2007 Jacq et al.; licensee BioMed Central Ltd.
|
Auteur(s) |
Laurent Jacq
1
, Sophie Garnier
1
, Philippe Dieudé
1
, Laëtitia Michou
1
, Céline Pierlot
2
, Paola Migliorini
, Alejandro Balsa
, René Westhovens
, Pilar Barrera
, Helena Alves
, Carlos Vaz
, Manuela Fernandes
3
, Dora Pascual-Salcedo
, Stefano Bombardieri
, Jan Dequeker
, Timothy R. Radstake
, Piet van Riel
, Leo van de Putte
, Antonio Lopes-Vaz
, Elodie Glikmans
, Sandra Barbet
1
, Sandra Lasbleiz
, Isabelle Lemaire
1
, Patrick Quillet
1
, Pascal Hilliquin
4, 1
, Vitor Hugo Teixeira
1
, Elisabeth Petit-Teixeira
1
, Hamdi Mbarek
1
, Bernard Prum
5
, Thomas Bardin
6, 1
, François Cornélis
1
1
GenHotel -
Laboratoire de recherche européen pour la polyarthrite rhumatoïde
( 1061669 )
- 2 rue Gaston Crémieux, CP5727, 91057 EVRY-GENOPOLE cedex
- France
2
UMR CNRS 8009 -
Laboratoire de Chimie Organique et Macromoleculaire
( 20668 )
- Universite des Sciences et Technologies, B.P. 90108, 59652, Villeneuve d'Ascq cedex, France
- France
3
CICECO -
Center for Research in Ceramic and Composite Materials
( 53123 )
- Department of Ceramics and Glass Engineering 3810-193 Aveiro
- Portugal
4
Centre Hospitalier Sud Francilien
( 184952 )
- 40 Avenue Serge Dassault - 91100 Corbeil-Essonnes
- France
5
LBBE -
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
( 10025 )
- 43 Bld du 11 Novembre 1918 69622 VILLEURBANNE CEDEX
- France
6
Service de Rhumatologie [CHU Lariboisière]
( 458984 )
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2007
|
Volume |
9
|
Numéro |
3
|
Domaine(s) |
|
Voir aussi |
|
DOI | 10.1186/ar2221 |
PubMed Central | PMC2206364 |
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