Stability constants and1H relaxation effects of ternary complexes formed between gd-dtpa, gd-dtpa-bma, gd-dota, and gd-edta and citrate, phosphate, and carbonate ions - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Magnetic Resonance in Medicine Année : 1997

Stability constants and1H relaxation effects of ternary complexes formed between gd-dtpa, gd-dtpa-bma, gd-dota, and gd-edta and citrate, phosphate, and carbonate ions

László Burai
  • Fonction : Auteur
Vesa Hietapelto
  • Fonction : Auteur
Róbert Király
  • Fonction : Auteur

Résumé

Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd-DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH < 8. The complex Gd-EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd-EDTA(X) (X = CO3(2-), Cit3-) results in a significant decrease in the proton relaxation rates under physiological conditions.

Dates et versions

hal-02080946 , version 1 (27-03-2019)

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Citer

László Burai, Vesa Hietapelto, Róbert Király, Éva Tóth, Ernő Brücher. Stability constants and1H relaxation effects of ternary complexes formed between gd-dtpa, gd-dtpa-bma, gd-dota, and gd-edta and citrate, phosphate, and carbonate ions. Magnetic Resonance in Medicine, 1997, 38 (1), pp.146-150. ⟨10.1002/mrm.1910380120⟩. ⟨hal-02080946⟩
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