High Relaxivity for Monomeric Gd(DOTA)-Based MRI Contrast Agents, Thanks to Micellar Self-Organization
Résumé
A new amphiphilic GdIII chelate, which is capable of forming micelles in aqueous solution (see diagram), has been synthesized. Due to this self‐aggregation, the compound has a long rotational correlation time and, consequently, has high proton relaxivities that thus far have only been obtained with macromolecular complexes.