Journal Articles Prenatal Diagnosis Year : 2018

Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses

Abstract

Lung hypoplasia and pulmonary arterial hypertension in congenital diaphragmatic hernia lead to a high perinatal mortality. Although sustained fetoscopic tracheal occlusion (TO) improves lung development, a major side effect is abnormal pneumocyte differentiation. This study evaluated the potential ability of intratracheal retinoic acid (RA) administration to reduce adverse effects of sustained TO in a rabbit model of diaphragmatic hernia.
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hal-01918664 , version 1 (11-11-2018)

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Amelie Delabaere, Loïc Blanchon, Karen Coste, Gael Clairefond, Corinne Belville, et al.. Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses. Prenatal Diagnosis, 2018, 38 (7), pp.482 - 492. ⟨10.1002/pd.5256⟩. ⟨hal-01918664⟩
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