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Article Dans Une Revue Carbohydrate Research Année : 2004

Synthesis of pentose-containing disaccharides using a thermostable α-l-arabinofuranosidase

Résumé

To date, the enzymatically-catalysed synthesis of pentose-containing compounds has been limited to the production of oligo-beta-(1-->3) and oligo-beta-(1-->4)-linked xylopyranosides. To our knowledge, no such syntheses have involved arabinofuranose or, indeed, any other sugars in the furanose configuration. In this report, we describe the use of a thermostable alpha-L-arabinofuranosidase for the synthesis of p-nitrophenyl alpha-L-arabinofuranosyl-(1-->2)-alpha-L-arabinofuranoside, p-nitrophenyl beta-D-xylopyranosyl-(1-->2)-beta-D-xylopyranoside, p-nitrophenyl beta-D-xylopyranosyl-(1-->3)-beta-D-xylopyranoside and benzyl alpha-D-xylopyranosyl-(1-->2)-alpha-L-arabinofuranoside. Importantly, this latter compound is synthesised in a highly regiospecific reaction, which leads to the production of a single disaccharide.

Dates et versions

hal-02073657 , version 1 (20-03-2019)

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Citer

Caroline Rémond, Richard Plantier-Royon, Nathalie Aubry, Emmanuel Maes, Christophe C. Bliard, et al.. Synthesis of pentose-containing disaccharides using a thermostable α-l-arabinofuranosidase. Carbohydrate Research, 2004, 339 (11), pp.2019-2025. ⟨10.1016/j.carres.2004.04.017⟩. ⟨hal-02073657⟩
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