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Article Dans Une Revue Molecular Nutrition and Food Research Année : 2005

Resveratrol and breast cancer chemoprevention: Molecular mechanisms

Résumé

Despite years of intensive research, breast cancer remains a major cause of death among women. New strategies to combat breast cancer are being developed, one of the most exciting of which is the use of chemopreventive agents. Resveratrol (RES) is a polyphenolic compound found in plants that seems to have a wide spectrum of biological activity. RES has been shown to afford protection against several types of cancer. This review summarizes the chemopreventive effects of RES at the three major stages of breast carcinogenesis: initiation, promotion, and progression. It has anti-oxidant and anti-inflammatory properties, and may induce apoptosis as well as modulate cell cycle and estrogen receptor function in breast cancer cell lines. Although RES has shown remarkable promise as a potent chemopreventive agent in breast cancer, further studies are needed to etablish its usefulness.

Domaines

Cancer

Dates et versions

hal-02071458 , version 1 (18-03-2019)

Identifiants

Citer

Ludovic Le Corre, Yves-Jean Bignon, Nassera Chalabi, Laetitia Delort, Yves Jean Bignon, et al.. Resveratrol and breast cancer chemoprevention: Molecular mechanisms. Molecular Nutrition and Food Research, 2005, 49 (5), pp.462-471. ⟨10.1002/mnfr.200400094⟩. ⟨hal-02071458⟩
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