The Minasarc study: A case-control study measuring mineral exposome in sarcoidosis
Michel Vincent
(1)
,
Catherine Cavalin
(2)
,
Mikael Catinon
,
Cécile Chemarin
(1, 3)
,
Stéphane Rio
(1)
,
Elisabeth Roux
(4)
,
Mathieu Pecquet
(1)
,
Anne-Sophie Blanchet
(5)
,
Sylvie Vuillermoz
(1)
,
Audrey Natalizio
,
Christophe Pison
(6, 7, 8)
,
François Arbib
(9)
,
Vincent Bonneterre
(10, 11)
,
Dominique Valeyre
(12)
,
Olivia Freynet
(13, 14, 15, 16)
,
Jean-Francois Mornex
(17, 18)
,
Nathalie Freymond
(19)
,
Yves Pacheco
(20)
,
Francoise Thivolet
(17)
,
Marianne Kambouchner
(21)
,
Jean-Francois Bernaudin
(22, 23)
,
Paul-André Rosental
(24)
1
Hôpital Saint Joseph
2 IRISSO - Institut de Recherche Interdisciplinaire en Sciences Sociales
3 INSAVALOR
4 ESPE Versailles - École supérieure du professorat et de l'éducation - Académie de Versailles
5 UB - Université de Bordeaux
6 LBFA - Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée
7 Centre Hospitalier Universitaire (CHU) de Grenoble, PôleThorax et Vaisseaux
8 UGA [2016-2019] - Université Grenoble Alpes [2016-2019]
9 Pneumology Department
10 TIMC-IMAG-EPSP - Environnement et Prédiction de la Santé des Populations
11 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
12 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
13 Service de Pneumologie [Bichat]
14 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
15 SU - Sorbonne Université
16 DHU FIRE Centre de compétence des maladies pulmonaires rares
17 Hôpital Louis Pradel [CHU - HCL]
18 IVPC - Infections Virales et Pathologie Comparée - UMR 754
19 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
20 EA 4271 - Immunovirologie et polymorphisme génétique
21 Service d’anatomie pathologique
22 CHU Tenon [AP-HP]
23 Sciences Po - Sciences Po
24 CHSP - Centre d'histoire de Sciences Po (Sciences Po)
2 IRISSO - Institut de Recherche Interdisciplinaire en Sciences Sociales
3 INSAVALOR
4 ESPE Versailles - École supérieure du professorat et de l'éducation - Académie de Versailles
5 UB - Université de Bordeaux
6 LBFA - Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée
7 Centre Hospitalier Universitaire (CHU) de Grenoble, PôleThorax et Vaisseaux
8 UGA [2016-2019] - Université Grenoble Alpes [2016-2019]
9 Pneumology Department
10 TIMC-IMAG-EPSP - Environnement et Prédiction de la Santé des Populations
11 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
12 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
13 Service de Pneumologie [Bichat]
14 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
15 SU - Sorbonne Université
16 DHU FIRE Centre de compétence des maladies pulmonaires rares
17 Hôpital Louis Pradel [CHU - HCL]
18 IVPC - Infections Virales et Pathologie Comparée - UMR 754
19 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
20 EA 4271 - Immunovirologie et polymorphisme génétique
21 Service d’anatomie pathologique
22 CHU Tenon [AP-HP]
23 Sciences Po - Sciences Po
24 CHSP - Centre d'histoire de Sciences Po (Sciences Po)
Catherine Cavalin
- Fonction : Auteur
- PersonId : 741563
- IdHAL : catherine-cavalin
- ORCID : 0000-0002-6037-3031
- IdRef : 149621604
Mikael Catinon
- Fonction : Auteur
Audrey Natalizio
- Fonction : Auteur
Christophe Pison
- Fonction : Auteur
- PersonId : 766182
- ORCID : 0000-0002-2152-6461
- IdRef : 066846692
Vincent Bonneterre
- Fonction : Auteur
- PersonId : 951859
- IdHAL : vincent-bonneterre
- ORCID : 0000-0003-2353-7102
- IdRef : 145775070
Paul-André Rosental
- Fonction : Auteur
- PersonId : 981813
- ORCID : 0000-0002-5208-6163
- IdRef : 050340638
Résumé
Introduction: it has been suggested that sarcoidosis could be associated with exposure to inorganic particles (Newman LS Curr Opin All Clin Immunol 2012; 12:145-50, Vincent M et al Am J Ind Med 2015; 58:S31-8).
Objectives: in order to test this hypothesis the Minasarc study was designed to evaluate the mineral exposome by a specific questionnaire (SQ) and a mineralogical analysis performed on BALs by optical and electron microscopy in patients and healthy volunteers (HV). We present here the results obtained by the SQ which can be considered as a tool for global assessment of the “whole life” exposure to inorganic particles in occupational and environmental contexts.
Methods: The study was performed on 20 patients with sarcoidosis and 20 HV. Every HV was matched to a patient by sex, age and smoking habit. The SQ was calibrated with a representative sample of the French population (n=825) in the ELIPSSilice survey (ANR-10-Eqpx-19-01) and the result was expressed as a “dust score”. Scores were compared by a Wilcoxon signed-rank test.
Results: The “dust score” was found significantly higher in patients with sarcoidosis than in HV (p=0,036; Wilcoxon signed-rank test). Moreover we found a significant overrepresentation of people exposed to building activities among the cases. However this remains to be assessed on a larger series.
Conclusion: The SQ demonstrated a significantly higher level of exposure to inorganic dusts in patients with sarcoidosis compared to HV. Such preliminary results encourage 1) to study the association between sarcoidosis and inorganic dust exposure and 2) to submit routinely this exposure questionnaire to every patient with a granulomatous disease.
