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Article Dans Une Revue The Journal of Physiology Année : 2016

Heterogeneous firing rate response of mouse layer V pyramidal neurons in the fluctuation-driven regime

Résumé

We recreated in vitro the fluctuation-driven regime observed at the soma during asynchronous network activity in vivo and we studied the firing rate response as a function of the properties of the membrane potential fluctuations. We provide a simple analytical template that captures the firing response of both pyramidal neurons and various theoretical models. We found a strong heterogeneity in the firing rate response of layer V pyramidal neurons: in particular, individual neurons differ not only in their mean excitability level, but also in their sensitivity to fluctuations. Theoretical modelling suggest that this observed heterogeneity might arise from various expression levels of the following biophysical properties: sodium inactivation, density of sodium channels and spike frequency adaptation.

Dates et versions

hal-02060248 , version 1 (07-03-2019)

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Yann Zerlaut, Bartosz Teleńczuk, Charlotte Deleuze, Gilles Ouanounou, Thierry Bal, et al.. Heterogeneous firing rate response of mouse layer V pyramidal neurons in the fluctuation-driven regime. The Journal of Physiology, 2016, 594 (13), pp.3791-3808. ⟨10.1113/JP272317⟩. ⟨hal-02060248⟩
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