Misidentification of recombinant hepatitis C virus leading to treatment failure with direct acting antivirals - Archive ouverte HAL Access content directly
Journal Articles Journal of Medical Virology Year : 2018

Misidentification of recombinant hepatitis C virus leading to treatment failure with direct acting antivirals

Thomas Mourez
  • Function : Author
Amandine Decroos
  • Function : Author
Odile Goria
  • Function : Author
Hélène Montialoux
  • Function : Author
Fabienne de Oliveira
  • Function : Author
Sylvie Larrat
  • Function : Author
  • PersonId : 873909

Abstract

The use of new Direct Acting Antivirals, specific of HCV, has greatly improved the HCV treatment. Most of the DAA are specific of HCV genotypes. Genotyping methods may target different regions of the HCV genome, though only the whole genome sequencing could confirm the correct genotype. The present study describes the virological investigation of a treatment failure due to the false identification of an unusual 2k/1b recombinant HCV form. It describes the sequencing methods, and the similarity analysis of the sequences to different genotype query sequences, to identify the recombination breakpoint.
Not file

Dates and versions

hal-02059883 , version 1 (07-03-2019)

Identifiers

Cite

Thomas Mourez, Amandine Decroos, Odile Goria, Hélène Montialoux, Fabienne de Oliveira, et al.. Misidentification of recombinant hepatitis C virus leading to treatment failure with direct acting antivirals. Journal of Medical Virology, 2018, 90 (5), pp.994-997. ⟨10.1002/jmv.25035⟩. ⟨hal-02059883⟩
42 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More