Assessment of bone vascularization and its role in bone remodeling - Archive ouverte HAL
Article Dans Une Revue (Article De Synthèse) BoneKEy Reports Année : 2015

Assessment of bone vascularization and its role in bone remodeling

Résumé

Bone is a composite organ that fulfils several interconnected functions, which may conflict with each other in pathological conditions. Bone vascularization is at the interface between these functions. The roles of bone vascularization are better documented in bone development, growth and modeling than in bone remodeling. However, every bone remodeling unitis associated with a capillary in both cortical and trabecularenvelopes. Here we summarize the most recent data on vessel involvement in bone remodeling, and we present the characteristics of bone vascularization. Finally, we describe the various techniques used for bone vessel imaging and quantitative assessment, including histology, immunohistochemistry, microtomography and intravital microscopy. Studying the role of vascularization in adult bone should provide benefits for the understanding and treatment of metabolic bone diseases.
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Dates et versions

hal-02058870 , version 1 (25-07-2024)

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Marie-Hélène Lafage-Proust, Bernard Roche, Max Langer, Damien Cleret, Arnaud Vanden Bossche, et al.. Assessment of bone vascularization and its role in bone remodeling. BoneKEy Reports, 2015, 4 (19), pp.662. ⟨10.1038/bonekey.2015.29⟩. ⟨hal-02058870⟩
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