Two-Step Synthesis of Substituted 3-Aminoindazoles from 2-Bromobenzonitriles - Archive ouverte HAL
Article Dans Une Revue Journal of Organic Chemistry Année : 2010

Two-Step Synthesis of Substituted 3-Aminoindazoles from 2-Bromobenzonitriles

Résumé

A general two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles involving a palladium-catalyzed arylation of benzophenone hydrazone followed by an acidic deprotection/cyclization sequence is described. This procedure offers a general and efficient alternative to the typical SNAr reaction of hydrazine with o-fluorobenzonitriles.

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Chimie organique

Thomas Cailly  : Connectez-vous pour contacter le contributeur

https://hal.science/hal-02045916

Soumis le : vendredi 22 février 2019-13:42:08

Dernière modification le : vendredi 24 mai 2024-15:58:17

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Dates et versions

hal-02045916 , version 1 (22-02-2019)

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Valérie Lefebvre, Thomas Cailly, Frédéric Fabis, Sylvain Rault. Two-Step Synthesis of Substituted 3-Aminoindazoles from 2-Bromobenzonitriles. Journal of Organic Chemistry, 2010, 75 (8), pp.2730-2732. ⟨10.1021/jo100243c⟩. ⟨hal-02045916⟩

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