Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-b peptide and relevant mutants
Résumé
Evaluation of Zn affinity for the amyloid-[small beta] peptide involved in Alzheimer's disease and its modified counterparts is reported. This was made possible by the use of a new water-soluble chelator, the properties of which have also been described. Changes in the peptide sequence that impact Zn affinity are briefly discussed.