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Article Dans Une Revue Advanced Drug Delivery Reviews Année : 2006

Freeze-drying of nanoparticles: Formulation, process and storage considerations

Résumé

Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.

Dates et versions

hal-02020761 , version 1 (15-02-2019)

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Citer

Wassim Abdelwahed, Ghania Degobert, Serge Stainmesse, Hatem Fessi. Freeze-drying of nanoparticles: Formulation, process and storage considerations. Advanced Drug Delivery Reviews, 2006, 58 (15), pp.1688-1713. ⟨10.1016/j.addr.2006.09.017⟩. ⟨hal-02020761⟩
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